科研动态国际PubMed 摘要
一项评估GB-K02培非格司亭生物类似药用于预防乳腺癌化疗所致中性粒细胞减少症的3期试验。A phase 3 trial of GB-K02 pegfilgrastim biosimilar for preventing chemotherapy-induced neutropenia in breast cancer.
化疗所致中性粒细胞减少症（CIN）在全球范围内构成巨大的疾病负担。尽管培非格司亭（一种长效粒细胞集落刺激因子）已显示出预防CIN的疗效，但其在中国尚未上市。这是中国首个评估培非格司亭生物类似药的临床研究。这项多中心、随机、双盲、平行对照的3期等效性研究旨在评估GB-K02（一种培非格司亭生物类似药）在250例乳腺癌患者中预防CIN的疗效和安全性。…
Chemotherapy-induced neutropenia (CIN) constitutes a substantial disease burden globally. Although pegfilgrastim (a long-acting granulocyte-colony stimulating factor) has demonstrated efficacy in preventing CIN, it is not yet available in China. This is the first clinical study to evaluate a pegfilgrastim biosimilar in China. This multicenter, randomized, double-blind, parallel-controlled, phase 3 equivalence study aims to evaluate the efficacy and safety of GB-K02 (a pegfilgrastim biosimilar) in preventing CIN among 250 patients with breast cancer.…
科研动态国际PubMed 摘要
碳酸氢钠林格液与乳酸林格液对幕上肿瘤切除术患者苏醒时间的影响：一项随机对照试验。Effects of Sodium Bicarbonate Ringer's Solution versus Lactate Ringer's Solution on Emergence Time in Patients Undergoing Supratentorial Tumor Resection: A Randomized Controlled Trial.
背景：在神经麻醉中，麻醉后迅速苏醒对于术后神经系统评估至关重要。术中输注碳酸氢钠林格液（BRS）与乳酸林格液（LRS）对内环境的影响不同，可能导致恢复情况的差异。因此，本研究旨在比较接受幕上肿瘤开颅手术的患者使用BRS与LRS的恢复情况。方法：本随机对照试验纳入了接受择期幕上肿瘤切除术的患者。……
BACKGROUND: In neuroanesthesia, a prompt emergence from anesthesia is essential for postoperative neurologic assessment. Intraoperative infusion of sodium bicarbonate Ringer's solution (BRS) and lactated Ringer's solution (LRS) have different effects on internal environment, potentially contributing to discrepant recovery profiles. Therefore, this study aimed to compare the recovery of BRS and LRS in patients undergoing craniotomy for supratentorial tumors. METHODS: This randomized controlled trial enrolled patients undergoing elective supratentorial tumor resection.…
科研动态国际PubMed 摘要
关于高负担国家镰状细胞病围产期筛查的定性证据综合。A qualitative evidence synthesis on perinatal screening for sickle cell disease in high-burden countries.
背景：镰状细胞病（SCD）筛查可以通过预防和靶向治疗改善生活并降低死亡率，但筛查项目在最能从中受益的环境中并未普遍可用。我们旨在利用健康社会生态学模型，了解在SCD活产患病率较高的国家中产前和新生儿SCD筛查项目的实施考虑因素。……
BACKGROUND: Sickle cell disease (SCD) screening can improve lives and reduce mortality through prevention and targeted treatment, but screening programmes are not universally available in the settings which could most benefit from them. We aimed to understand the implementation considerations for prenatal and newborn SCD screening programmes in countries with a high livebirth prevalence of SCD using the socioecological model of health.…
科研动态国际PubMed 摘要
BPC-157在骨科与再生医学中的人体证据：疗效与安全性的系统评价。Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety.
或联系 mzyjp23@nottingham.ac.uk — 人体保护性化合物157（BPC-157）是一种合成的十五肽，在运动员群体中广泛用于肌肉骨骼损伤的恢复，尽管其尚未获得监管机构批准用于人体，且证据主要局限于动物模型。本系统评价遵循PRISMA规范，并已在PROSPERO前瞻性注册（注册号CRD420261406325），旨在评估BPC-157在人体骨科与再生用途中的疗效和安全性。电子数据库（Embase、PubMed、Cochrane Library及ClinicalTrials.gov）检索截止至2026年6月1日。…（注：原文此处以省略号结尾，按原文保留）
or mzyjp23@nottingham.ac.uk Body Protective Compound-157 (BPC-157) is a synthetic pentadecapeptide popular among athletic populations for musculoskeletal injury recovery, despite lacking regulatory approval for human use and evidence being largely limited to animal models. This PRISMA-compliant systematic review, prospectively registered with PROSPERO (CRD420261406325), aimed to evaluate the efficacy and safety of BPC-157 for orthopaedic and regenerative purposes in humans. Electronic databases (Embase, PubMed, Cochrane Library and ClinicalTrials.gov) were searched up to 1 June 2026.…
科研动态国际PubMed 摘要
校园欺凌案件中证词评估的全球评估系统测试。Testing the Evaluation of the Testimony of the Global Evaluation System in Bullying Cases.
背景/目的：校园欺凌受害的发生率估计在儿童和青少年中的5%（严格的发生率分类标准）至33%（宽松的发生率评估标准）之间。欺凌受害涉及行政（学校环境）、民事（受害者赔偿）和刑事（刑事责任）层面的决策，这些决策必须基于对指控真实性的确定性。…
Background/aim: The prevalence of school bullying victimization has been estimated between 5% (strict criteria for prevalence classification) and 33% (lenient criteria for prevalence assessment) of children and adolescents. Bullying victimization entails decision-making at the administrative (school setting), civil (victim compensation), and criminal (criminal responsibility) levels, which must be based on certainty about the truthfulness of the allegation.…
科研动态国际PubMed 摘要
快速康复方案下全膝关节置换术后采用加压治疗预防血栓栓塞性疾病：一项系统综述。Compression therapy in the prevention of thromboembolic disease following total knee arthroplasty with a fast recovery protocol: A systematic review.
血栓栓塞性疾病（TED），包括深静脉血栓形成（DVT）和肺栓塞（PE），仍是全膝关节置换术（TKA）后的一种严重术后风险。加速康复外科（ERAS）方案强调早期活动，因此有必要重新评估机械性预防措施，如加压治疗。本系统综述评价了在ERAS方案联合药物预防下，加压治疗对TKA患者预防TED的获益。…
Thromboembolic disease (TED), including deep vein thrombosis (DVT) and pulmonary embolism (PE), remains a serious postoperative risk after total knee arthroplasty (TKA). Enhanced recovery after surgery (ERAS) protocols emphasize early mobilization, warranting reassessment of mechanical prophylaxis, such as compression therapy. This systematic review evaluates the benefits of compression therapy in preventing TED in TKA patients under ERAS protocols combined with pharmacological prophylaxis.…
科研动态国际PubMed 摘要
急性脑出血中按血肿部位降压治疗的效果。Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage.
背景与目的：早期强化降压（BP）目前已被认为是改善急性脑出血（ICH）后预后的有效方法。然而，其效果是否因血肿部位不同而存在差异尚不明确。我们旨在确定强化降压对功能结局的治疗效果是否因血肿部位不同而存在异质性。…
BACKGROUND AND OBJECTIVES: Early intensive blood pressure (BP) lowering is now recognized as an effective approach to improve outcome after acute intracerebral hemorrhage (ICH). However, whether the effect varies by hematoma location is uncertain. We aimed to determine the heterogeneity of the treatment effect of intensive BP lowering on functional outcome by hematoma location.…
科研动态国际PubMed 摘要
2型糖尿病成人启动GLP-1受体激动剂、SGLT-2抑制剂、替尔泊肽和非奈利酮的价值观、偏好与治疗负担：系统评价。Values, preferences, and treatment burden for initiation of GLP-1 receptor agonists, SGLT-2 inhibitors, tirzepatide, and finerenone in adults with type 2 diabetes: systematic review.
目的：总结关于2型糖尿病成人在考虑启动胰高血糖素样肽-1受体激动剂（GLP-1 RA）、钠-葡萄糖协同转运蛋白2抑制剂（SGLT-2i）、非奈利酮或替尔泊肽时的价值观、偏好和感知治疗负担的现有证据。设计：系统评价。数据来源：检索Medline、Embase、Scopus、Web of Science和Cochrane对照试验中心注册库，检索时间自建库至2025年1月7日（更新此前一项纳入了截至2020年5月23日文献的系统评价）。…
OBJECTIVES: To summarise existing evidence regarding the values, preferences, and perceived treatment burden of adults with type 2 diabetes when considering initiation of glucagon-like peptide-1 receptor agonists (GLP-1 RA), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), finerenone, or tirzepatide. DESIGN: Systematic review. DATA SOURCES: Medline, Embase, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched from database inception to 7 January 2025 (updating a previous systematic review that captured literature up to 23 May 2020).…
科研动态国际PubMed 摘要
动脉瘤性蛛网膜下腔出血血管内弹簧圈栓塞与显微外科夹闭的疗效和安全性：随机试验的系统评价与荟萃分析。Efficacy and safety of endovascular coiling compared to microsurgical clipping in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis of randomized trials.
背景：尽管动脉瘤修复技术不断进步，动脉瘤性蛛网膜下腔出血（aSAH）仍具有较高的致残率和死亡率。显微外科夹闭和血管内弹簧圈栓塞是公认的治疗方式，但二者在功能结局和动脉瘤长期闭塞方面的相对获益仍存在争议。本研究按动脉瘤位置和临床分级分层评估治疗效果。方法：我们检索了比较夹闭与弹簧圈栓塞治疗破裂颅内动脉瘤的随机对照试验。…
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) carries high morbidity and mortality despite advances in aneurysm repair. Microsurgical clipping and endovascular coiling are established treatment modalities, yet their relative benefits regarding functional outcome and long-term aneurysm occlusion remain debated. This study evaluates treatment effects stratified by aneurysm location and clinical grade. METHODS: We identified RCTs comparing clipping and coiling for ruptured intracranial aneurysms.…
科研动态国际PubMed 摘要
重组带状疱疹疫苗在自身免疫性风湿病中的前瞻性对照研究：尽管使用静脉注射环磷酰胺，仍出现强效血清学转换。Prospective controlled study of the recombinant zoster vaccine in autoimmune rheumatic disease: robust seroconversion despite intravenous cyclophosphamide.
背景：重组带状疱疹疫苗（RZV）可预防自身免疫性风湿病（ARD）患者的带状疱疹，但静脉注射环磷酰胺（IVCYC）对免疫原性的影响尚不清楚。鉴于细胞耗竭/细胞毒性作用，预期IVCYC会诱导显著的免疫原性损害，因此我们评估了其影响。方法：这项对前瞻性、随机、安慰剂对照试验的亚分析纳入了接受IVCYC的ARD患者（ARD-IVCYC），并与未接受IVCYC的患者（ARD-no IVCYC）及健康对照者进行比较。RZV分两剂接种。…
BACKGROUND: Recombinant zoster vaccine (RZV) prevents shingles in autoimmune rheumatic diseases (ARD), but intravenous cyclophosphamide (IVCYC) impact on immunogenicity is unknown. Given cell depletion/cytotoxicity, IVCYC is expected to induce profound immunogenicity impairment, we therefore evaluated its impact. METHODS: This subanalysis of prospective, randomized, placebo-controlled trial included ARD patients receiving IVCYC (ARD-IVCYC) compared with patients without IVCYC (ARD-no IVCYC) and healthy-controls. RZV was administered in two doses.…
科研动态国际PubMed 摘要
儿童非重症社区获得性肺炎的短疗程与长疗程抗生素治疗：一项系统评价和荟萃分析。Short- versus long-course antibiotic therapy in non-severe CAP in children: a systematic review and meta-analysis.
无标注：优化儿童社区获得性肺炎（CAP）的抗生素疗程可能减少治疗负担并支持抗菌药物管理。尽管近期随机试验和证据综合报告了较短抗生素疗程可获得相似的临床结局，但治疗持续时间对依从性的影响——在儿童中尤为相关的考虑因素——受到相对有限的系统评价。…
UNLABELLED: Optimizing antibiotic duration for pediatric community-acquired pneumonia (CAP) may reduce treatment burden and support antimicrobial stewardship. Although recent randomized trials and evidence syntheses have reported similar clinical outcomes with shorter antibiotic courses, the effect of treatment duration on adherence-an especially relevant consideration in children-has received comparatively limited systematic evaluation.…
科研动态国际PubMed 摘要
需要接受有创机械通气的危重成人和儿童患者中，每日镇静中断与不进行每日镇静中断的比较。Daily sedation interruption versus no daily sedation interruption for critically ill adults and children requiring invasive mechanical ventilation.
理论基础：每日镇静中断（DSI）旨在限制药物蓄积并促进更清醒的状态，从而缩短机械通气时间及其相关并发症。本文是对2014年首次发表的Cochrane系统评价的更新。…
RATIONALE: Daily sedation interruption (DSI) aims to limit drug accumulation and promote a more awake state, thereby reducing the duration of mechanical ventilation and its associated complications. This is an update of a Cochrane review first published in 2014.…
科研动态国际PubMed 摘要
ACR 适当性标准®：疑似膈肌功能障碍。ACR Appropriateness Criteria® Suspected Diaphragm Dysfunction.
膈肌功能障碍包括膈肌膨出、无力和麻痹，这是一组因症状表现多样（包括呼吸困难、体位性端坐呼吸、咳嗽，甚至胸痛）而常难以临床诊断的疾病。鉴于临床诊断这些疾病存在挑战，膈肌功能障碍常在针对这些症状的初步影像检查中被偶然发现。…
Diaphragm dysfunction includes diaphragmatic eventration, weakness, and paralysis, a set of disorders which are often challenging to diagnose clinically due to their varied presenting symptoms including dyspnea, positional orthopnea, cough, or even chest pain. Given the clinical challenge in diagnosing these conditions, diaphragm dysfunction is often suggested incidentally on initial imaging for workup of these symptoms.…
科研动态国际PubMed 摘要
碳离子放射治疗开放入组临床研究的全球格局：一项PTCOG综述。Global Landscape of Clinical Studies Open to Enrollment in Carbon Ion Radiotherapy: A PTCOG Review.
背景：高线性能量传递（LET）放疗已显示出改善癌症结局的前景。碳离子放射治疗（CIRT）将带电粒子的剂量适形性与增强的生物有效性相结合。然而，临床开发仍受到中心可及性有限、试验入组规模不大以及随机研究较少的制约。我们综述了全球范围内开放入组的CIRT研究格局，以明确当前的重点与不足。…
BACKGROUND: Radiotherapy with high linear energy transfer (LET) has shown promise for improving cancer outcomes. Carbon ion radiotherapy (CIRT) combines charged-particle dose conformality with enhanced biological effectiveness. However, clinical development remains constrained by limited center availability, modest trial accrual, and few randomized studies. We reviewed the global landscape of CIRT studies open to enrollment to identify current priorities and gaps.…
科研动态国际PubMed 摘要
微创与胸骨切开术在再次二尖瓣手术中的比较：基于meta回归和事件时间分析的短期及长期结局。Minimally Invasive Versus Sternotomy in Redo Mitral Valve Surgery: Short- and Long-Term Outcomes with Meta-Regression and Time-to-Event Analysis.
背景：再次二尖瓣手术具有相当大的风险，微创二尖瓣手术（MI-MVS）与胸骨切开术二尖瓣手术相比的相对获益，尤其是在长期生存方面，仍不明确。方法：检索电子数据库，纳入比较成人再次二尖瓣手术中MI-MVS与胸骨切开术二尖瓣手术的研究。对Kaplan-Meier曲线进行数字化处理，以重建个体患者数据进行事件时间分析，并使用Cox frailty模型生成研究层面的风险比（HR）。围手术期结局采用随机效应模型进行汇总。…
BACKGROUND: Redo mitral valve surgery carries substantial risk, and the relative benefits of minimally invasive (MI-MVS) versus sternotomy MVS, particularly regarding long-term survival, remain uncertain. METHODS: Electronic databases were searched for studies comparing MI-MVS with sternotomy MVS in adult redo MVS. Kaplan-Meier curves were digitized to reconstruct individual patient data for time-to-event analysis, with study-level hazard ratios (HR) generated using a Cox frailty model. Perioperative outcomes were pooled using random-effects models.…
科研动态国际PubMed 摘要
系统性炎症反应综合征与急性脑出血不良结局：一项荟萃分析。Systemic inflammatory response syndrome and adverse outcomes in acute intracerebral hemorrhage: a meta-analysis.
目的：系统性炎症反应综合征（SIRS）常并发于急性脑出血（ICH），并可能影响患者预后。然而，SIRS在急性脑出血患者中的预后价值仍存在争议。本荟萃分析旨在评估SIRS在该患者人群中的预后意义。方法：我们系统检索了PubMed、Embase和Web of Science，以识别探讨SIRS与急性脑出血患者不良结局（即死亡、不良功能结局（PFO）和血肿扩大）之间关联的研究。…
OBJECTIVE: Systemic inflammatory response syndrome (SIRS) frequently complicates acute intracerebral hemorrhage (ICH) and may affect patient prognosis. However, the prognostic value of SIRS in patients with acute ICH remains controversial. This meta-analysis aimed to assess the prognostic significance of SIRS in this patient population. METHODS: We systematically searched PubMed, Embase, and Web of Science to identify studies investigating the associations between SIRS and adverse outcomes-namely mortality, poor functional outcome (PFO), and hematoma expansion-in patients with acute ICH.…
科研动态国际PubMed 摘要
媒体诱发的针对青少年的间接创伤：基于COSMIN的测量工具及其心理测量学适用性的系统评价Media-induced indirect trauma for adolescents: a COSMIN-based systematic review of measurement instruments and their psychometric suitability.
背景：通过持续不断的新闻和社交媒体对灾难和暴力的间接接触在青少年中日益普遍。……
Background: Indirect exposure to disasters and violence through continuous news and social media is increasingly common among adolescents.…
科研动态国际PubMed 摘要
苯二氮䓬类药物对心力衰竭结局和不良事件的影响：系统综述与Meta分析。Effects of Benzodiazepines on Heart Failure Outcomes and Adverse Events: A Systematic Review and Meta-Analysis.
苯二氮䓬类药物（BZDs）治疗失眠对心力衰竭（HF）的影响仍不明确，尤其是在高危人群中。通过检索七个数据库，从建库至2025年8月7日，筛选出相关研究。提取了与心力衰竭相关结局相关的风险比（HR）或相对风险估计值。采用随机效应模型进行Meta分析，并使用纽卡斯尔-渥太华量表（NOS）评估研究质量。11项研究符合纳入标准，随访时长为180天至15年。…
The effects of benzodiazepines (BZDs) for insomnia on heart failure (HF) remain unclear, particularly among high-risk populations. Relevant studies were retrieved by searching seven databases from inception to August 7, 2025. Hazard ratios (HRs) or risk ratios estimated for related HF outcomes were extracted. Meta-analyses were conducted using a random-effects model, and study quality was assessed using the Newcastle-Ottawa Scale (NOS). Eleven studies met the inclusion criteria, with follow-up durations ranging from 180 days to 15 years.…
科研动态国际PubMed 摘要
脉冲场消融治疗持续性和长程持续性心房颤动的疗效、安全性及策略调整因素：一项系统综述和荟萃分析。Efficacy, safety, and strategy-modifying factors of pulsed field ablation for persistent and long-standing persistent atrial fibrillation: a systematic review and meta-analysis.
背景：脉冲场消融（PFA）越来越多地应用于持续性心房颤动（PerAF）和长程持续性心房颤动（LSPAF）。先前针对混合房颤人群的综述提示，其在手术效率和食管安全性方面具有潜在优势，但针对PerAF/LSPAF的长期心律结局以及后壁或扩展基质策略价值的特异性证据仍然有限，且在消融径线组合、终点定义和对照类型方面存在显著异质性。…
BACKGROUND: Pulsed field ablation (PFA) is increasingly applied in persistent atrial fibrillation (PerAF) and long-standing persistent atrial fibrillation (LSPAF). Previous reviews of mixed AF populations suggested potential advantages in procedural efficiency and esophageal safety, but PerAF/LSPAF-specific evidence on long-term rhythm outcomes and on the value of posterior wall or extended substrate strategies remains limited, with substantial heterogeneity in lesion sets, endpoint definitions, and comparator types.…
科研动态国际PubMed 摘要待译
Systematic review and meta-analysis: the effectiveness of cognitive behavioral therapy and eye movement desensitization and reprocessing in children and adolescents.Background: Post-traumatic stress disorder (PTSD) is prevalent among children and adolescents, with cognitive behavioral therapy (CBT) and eye movement desensitization and reprocessing (EMDR) widely used treatment options. This study compared the effects of CBT and EMDR in children and adolescents using a meta-analysis approach.Methods: PubMed, EMBASE, CENTRAL, CINAHL, ProQuest Dissertations & Theses, and PsycInfo were searched in March 2025.…