英国新生儿单纯疱疹病毒感染发病率25年间增加两倍
英国儿科监测单位第三次调查显示，出生后90天内单纯疱疹病毒(HSV)感染的年发病率在过去25年增加了两倍，达到6/10万活产。实验室数据显示发病率可能为13.7/10万活产，提示存在漏报。尽管罕见，新生儿HSV仍是重要疾病，总体死亡率和致残率高达23.9%。
要点
- 英国新生儿HSV感染发病率25年间增加两倍，目前为6/10万活产
- 实验室数据显示实际发病率可能达13.7/10万活产
- 新生儿HSV总体死亡率和致残率为23.9%
核心结论
- 尽管新生儿单纯疱疹病毒感染罕见，但因其持续高死亡率和致残率(23.9%)仍是重要疾病
研究设计与样本
- 英国儿科监测单位(BPSU)第三次调查，纳入出生后90天内出现HSV感染的婴儿
- 调查数据与英国卫生安全局实验室常规数据进行对比分析
主要发现
- 英国新生儿HSV感染年发病率在过去25年增加了两倍
- BPSU调查报告的发病率为6/10万活产
- 实验室数据显示发病率为13.7/10万活产，提示BPSU调查存在漏报
- 总体死亡率和致残率为23.9%
- 大多数儿科医生/新生儿科医生在职业生涯中仅会遇到少数病例
局限性
- BPSU调查可能存在病例漏报
以上解读依据论文摘要（全文未开放获取或许可不允许翻译转载）。
原文
The third British Paediatric Surveillance Unit (BPSU) survey of herpes simplex virus (HSV) infection in infants presenting before 90 days of age, reported in May (2026) edition of Archives , informs us that the annual UK incidence has tripled over the last 25 years. However, this remains a rare condition (6 per 100 000 live births), and most paediatricians/neonatologists will see less than a handful of cases in their working life. 1 During the same time period, routine laboratory data from the UK Health Security Agency reports double the incidence (13.7/100 000 births), suggesting under-reporting to the BPSU survey. This also reflects the concomitant increasing national incidence of sexually transmitted infections ( Sexually transmitted infections and screening for chlamydia in England: 2024 report - GOV.UK ). Despite its rarity, neonatal HSV remains a very important condition due to its persistently high mortality and morbidity. Overall, 23.9% of babies...
引用
- Archives of Disease in Childhood：Infants at highest risk of herpes simplex virus disease who should start immediate empiric aciclovir
供执业医师工作参考，不替代临床判断；数值与分级以指南原文为准。