PEN-FAST 青霉素过敏决策规则
用途适用： remote or unclear penicillin allergy labels when stewardship/delabeling is considered.
分层Score <3 → published low risk (<5%); consider supervised DOC per protocol. ≥3 → allergy evaluation preferred.
局限不适用： recent anaphylaxis or SCAR — do not direct-challenge. · 易错点： confusing non-allergic intolerance with IgE/SCAR history. · Follow institutional allergy pathways.
出处Trubiano JA, et al. JAMA Intern Med 2020 (PEN-FAST)
本班次下一步
评完分数后：进场景连算、看相邻评分、打开对应路径。本地参考，不写入 HIS。
方法学 · 公式代入、指南要点与完整说明
适用场景
适用： remote or unclear penicillin allergy labels when stewardship/delabeling is considered.
需要填写的项目
- Five years or less since reaction (or unknown timing) · 选项
- Anaphylaxis / angioedema OR severe cutaneous adverse reaction (SCAR) · 选项
- Treatment required for the reaction (or unknown) · 选项
计算方法与公式
≤5 years since reaction or unknown (2) + anaphylaxis/angioedema or SCAR (2) + treatment required or unknown (1). 0–5.
Interview history; score <3 often low risk for true allergy in validation.
公式代入演示
下列数值取自本工具各输入项的示例值，用本页公式在服务端实际算出，供快速核对计算过程。仅演示代入方法，不构成临床建议，也不代表任何真实病例。
| Five years or less since reaction (or unknown timing) | No — >5 y ago (0) |
|---|---|
| Anaphylaxis / angioedema OR severe cutaneous adverse reaction (SCAR) | 否 (0) |
| Treatment required for the reaction (or unknown) | 否 (0) |
→PEN-FAST0/5
- Band：Low risk of true allergy (<5% in validation) — DOC pathways often considered
- Cutoff：<3 low risk
| Five years or less since reaction (or unknown timing) | Yes / unknown (2) |
|---|---|
| Anaphylaxis / angioedema OR severe cutaneous adverse reaction (SCAR) | 是 (2) |
| Treatment required for the reaction (or unknown) | Yes / unknown (1) |
→PEN-FAST5/5
- Band：Elevated risk (≥3) — allergy evaluation / testing preferred before rechallenge
- Cutoff：<3 low risk
结果判读与分层
Score <3 → published low risk (<5%); consider supervised DOC per protocol. ≥3 → allergy evaluation preferred.
指南要点（原创整理）
- Cutoff <3 low risk.
- Adapted interview tool.
- 下一步： SULF-FAST / allergy referral.
以上为依据相应指南的关键推荐、由本站用自己的语言归纳整理（非指南原文）；完整内容请见下方官方来源。
注意事项与局限
- 不适用： recent anaphylaxis or SCAR — do not direct-challenge.
- 易错点： confusing non-allergic intolerance with IgE/SCAR history.
- Follow institutional allergy pathways.
核对与出处 · 可验证治理
参考指南与出处
- Trubiano JA, et al. JAMA Intern Med 2020 (PEN-FAST) · 来源 ↗
指南全文版权归相应学会/期刊所有；本工具仅实现其决策算法并注明出处，全文请经上方官方来源获取。
依据文献年份见参考 · 数据集整理日 2026-10-08
常见问题
常见问题
- PEN-FAST 青霉素过敏决策规则的计算是否上传患者数据？在哪里计算？
- 计算在浏览器本地完成，输入与结果不上传服务器；结果仅供执业医师参考，须结合病史、检查与本机构方案判断，不构成诊断或处方依据。
- PEN-FAST 青霉素过敏决策规则怎么代入计算？能举个例子吗？
- 代入: Five years or less since reaction (or unknown timing) No — >5 y ago (0)、Anaphylaxis / angioedema OR severe cutaneous adverse reaction (SCAR) 否 (0)、Treatment required for the reaction (or unknown) 否 (0) → 结果: PEN-FAST 0 /5（Band: Low risk of true allergy (<5% in validation) — DOC pathways often considered、Cutoff: <3 low risk） 代入: Five years or less since reaction (or unknown timing) Yes / unknown (2)、Anaphylaxis / angioedema OR severe cutaneous adverse reaction (SCAR) 是 (2)、Treatment required for the reaction (or unknown) Yes / unknown (1) → 结果: PEN-FAST 5 /5（Band: Elevated risk (≥3) — allergy evaluation / testing preferred before rechallenge、Cutoff: <3 low risk）
核对流程与方法学
核对与依据
本工具的公式与计算方法已在本页明示、公开可逐一核查。其公式、系数与阈值依据上方「参考指南与出处」列出的权威来源核对。想了解本站对全部临床工具的核对流程与出处覆盖情况，见 临床工具核对表与方法学 →