💊 Vancomycin AUC24 (Two-Level Trapezoid)
UseWhen to use: AUC-guided vancomycin monitoring when two timed levels around an interval are available.
StrataTeaching target band AUC24≈400–600 (MIC=1 → AUC/MIC≈400); align with China vancomycin TDM consensus when cite…
LimitsWhen not to use: non-steady state / mistimed levels unexplained. · Pitfall: skipping Bayesian software when available. · Cannot: change dose from trapezoid alone; replace ID consult or local…
SourceVancomycin AUC24 two-level trapezoidal teaching estimate
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Two-level trapezoid.
When to use
When to use: AUC-guided vancomycin monitoring when two timed levels around an interval are available.
How it works
Ke=ln(Cmax/Cmin)/(τ−t_inf); AUC24=(AUC_inf+AUC_elim)×(24/τ).
Key points
- Two-level trapezoid.
- AUC24 target band.
- Next: Bayesian / CrCl / MIC.
References
- Vancomycin AUC24 two-level trapezoidal teaching estimate
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Post-infusion peak (Cmax) | 35 mg/L |
|---|---|
| Trough (Cmin) before next dose | 12 mg/L |
| Infusion duration | 1 h |
| Dosing interval (τ) | 12 h |
| MIC (optional) | 1 mg/L |
→AUC24520mg·h/L
- Ke：0.097 /h
- AUC_τ：260 mg·h/L
- AUC24：520 mg·h/L
Verification & sources · governance
FAQ
Frequently asked questions
- Does Vancomycin AUC24 (Two-Level Trapezoid) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Vancomycin AUC24 (Two-Level Trapezoid) calculated in practice? Can you show a worked example?
- Inputs: Post-infusion peak (Cmax) 35 mg/L, Trough (Cmin) before next dose 12 mg/L, Infusion duration 1 h, Dosing interval (τ) 12 h, MIC (optional) 1 mg/L → Result: AUC24 520 mg·h/L（Ke: 0.097 /h, AUC_τ: 260 mg·h/L, AUC24: 520 mg·h/L）