📐 Antibiotic PK/PD Dosing Strategy
UseChoose a dosing strategy that matches the drug's PK/PD class to improve efficacy and suppress resistance.
SourceCraig WA. Pharmacokinetic/pharmacodynamic parameters. Clin Infect Dis 1998
This-shift next steps
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Methodology · worked example, guidelines & full notes
Extend or continuously infuse β-lactams in severe/high-MIC infection.
When to use
Choose a dosing strategy that matches the drug's PK/PD class to improve efficacy and suppress resistance.
How it works
Time-dependent (β-lactams) maximise fT > MIC; concentration-dependent (aminoglycosides/quinolones) maximise Cmax/MIC; AUC-type (vancomycin) maximise AUC/MIC.
Key points
- Extend or continuously infuse β-lactams in severe/high-MIC infection.
- Give aminoglycosides once-daily to raise the peak and exploit the PAE.
- Targets are MIC-based — account for the isolate MIC and tissue penetration.
- Augmented renal clearance needs higher doses / TDM.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| View | AUC/MIC type |
|---|
→PK/PDAUC/MIC type (mixed)
- Representatives：Vancomycin, azithromycin, tetracyclines, linezolid
- Targets：Vancomycin AUC/MIC 400–600 (MIC 1); overall maximise 24 h AUC
- Strategy：Ensure total daily exposure/AUC; vancomycin by AUC/TDM (see the vancomycin tool)
| View | Time-dependent (T > MIC) |
|---|
→PK/PDTime-dependent (T > MIC)
- Representatives：β-lactams (penicillins/cephalosporins/carbapenems), aztreonam; clindamycin
- Targets：fT > MIC: carbapenems ~40%, penicillins ~50%, cephalosporins ~60–70%; severe/high-MIC aim for 100% fT > MIC or 4× MIC
- Strategy：Shorten the interval, extend/continuous infusion to increase T > MIC; simply raising the dose gives limited extra killing
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using Antibiotic PK/PD Dosing Strategy?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does Antibiotic PK/PD Dosing Strategy upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Antibiotic PK/PD Dosing Strategy calculated in practice? Can you show a worked example?
- Inputs: View AUC/MIC type → Result: PK/PD AUC/MIC type (mixed)（Representatives: Vancomycin, azithromycin, tetracyclines, linezolid, Targets: Vancomycin AUC/MIC 400–600 (MIC 1); overall maximise 24 h AUC, Strategy: Ensure total daily exposure/AUC; vancomycin by AUC/TDM (see the vancomycin tool)） Inputs: View Time-dependent (T > MIC) → Result: PK/PD Time-dependent (T > MIC)（Representatives: β-lactams (penicillins/cephalosporins/carbapenems), aztreonam; clindamycin, Targets: fT > MIC: carbapenems ~40%, penicillins ~50%, cephalosporins ~60–70%; severe/high-MIC aim for 100% fT > MIC or 4× MIC, Strategy: Shorten the interval, extend/continuous infusion to increase T > MIC; simply raising the dose gives limited extra killing）