💉 Vancomycin Empiric Dosing
UseChoose an empiric starting regimen for adults; it does not replace TDM/Bayesian AUC adjustment, which should …
SourceRybak MJ, et al. ASHP/IDSA/SIDP/PIDS therapeutic monitoring of vancomycin. 2020
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Start by actual body weight; in obesity load 20–25 mg/kg and monitor earlier.
When to use
Choose an empiric starting regimen for adults; it does not replace TDM/Bayesian AUC adjustment, which should be obtained within 24–48 h.
How it works
Loading 25 mg/kg actual weight (cap 3000 mg); maintenance 15–20 mg/kg; interval by CrCl (≥ 90 q8–12h, 50–89 q12h, 20–49 q24h). Target AUC/MIC 400–600.
Key points
- Start by actual body weight; in obesity load 20–25 mg/kg and monitor earlier.
- Obtain TDM early — the formula alone cannot guarantee the AUC target.
- AKI, haemodialysis and CRRT require separate dosing approaches.
- Monitor renal function; avoid stacking nephrotoxins.
References
- [Guideline / primary source]Rybak MJ, et al. ASHP/IDSA/SIDP/PIDS therapeutic monitoring of vancomycin. 2020
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using Vancomycin Empiric Dosing?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does Vancomycin Empiric Dosing upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.