Gd-EOB-DTPA与Gd-DTPA增强MR对肝硬化患者肝血管和肝实质增强效果的自身对照研究-Comparative study of using Gd-EOB-DTPA and Gd-DTPA as MR contrast agent for hepatic parenchyma and vessles enhacement in the same patient with cirrhosis

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【摘要】目的：自身对照比较Gd-EOB-DTPA与Gd-DTPA增强MR对肝硬化患者的肝动脉、门静脉和肝实质强化效果的差异。方法：回顾性分析35例肝硬化患者的Gd-EOB-DTPA与Gd-DTPA增强MR图像，计算肝总动脉、门静脉和肝实质的强化比率（PE）和肝总动脉、门静脉与肝实质的相对对比度（RC），并统计是否存在差异。结果：Gd-EOB-DTPA增强MR肝总动脉、门静脉的平均PE明显低于Gd-DTPA（P<0.05）。Gd-EOB-DTPA的门脉期肝实质的平均PE明显低于Gd DTPA（P<0.05）而动脉期肝实质的PE值无明显差异（P=0.1010）。肝总动脉、门静脉与肝实质的RC值Gd-DTPA增强MR略高于Gd-EOB-DTPA，但是无明显统计学差异（P分别为0.3421和0.2389）。结论：肝硬化患者Gd-EOB-DTPA增强MR的肝血管和肝实质效果低于Gd-DTPA, Gd-EOB-DTPA的剂量需要进一步调整。;【Abstract】Objective：To evaluate the differences of enhance effects of common hepatic artery (CHA),portal vein (PV) and hepatic parenchyma on dynamic contrast enhanced (DCE) MRI by using gadolinium ethoxybenzyldiethylenetriamine pentaacetic acid (Gd-EOB-DTPA) and gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) separately in the same cirrhotic patient.Methods:The enhanced MR images of liver in 35 cirrhotic patients obtained by using Gd-EOB-DTPA and Gd-DTPA separately in the same patient were reviewed.The percentage enhancement (PE) of CHA,PV and hepatic parenchyma and the relative contrast (RC) between CHA,PV and hepatic parenchyma were calculated and analyzed statistically.Results:The mean PEs of CHA,PV were significantly lower forGd-EOB-DTPA than Gd-DTPA （P<0.05）.The mean PE of hepatic parenchyma at portal phase using Gd-EOB-DTPA was markedly lower than that using Gd-DTPA（P<0.05）,whereas there was no significant difference of the mean PE of hepatic parenchyma at arterial phase （P=0.1010）.The RC values of CHA,PV and hepatic parenchyma using Gd-DTPA was slightly higher than that using Gd-EOB-DTPA,yet with no significant statistic difference （P=0.3421 and 0.2389 respectively）.Conclusion:Compared with Gd-DTPA,the enhance effect of Gd-EOB-DTPA was lower in hepatic vessels and hepatic parenchyma in patients with cirrhosis,adjustment of the dosage of Gd-EOB-DTPAshould be considered.