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低强度脉冲超声改善肥胖诱导的肝脏脂质代谢紊乱

Low-intensity Pulsed Ultrasound Ameliorates Obesity-induced Hepatic Lipid Metabolic Disorders.
PubMed 文献 · Ultrasound Med Biol · 2026-05-20

结果显示LIPUS显著改善肥胖、血脂异常、肝功能障碍和肝脂肪变性，机制涉及Piezo1-PI3K/AKT通路调控肝脏脂质代谢酶及FGF21驱动脂肪组织棕色化。

要点

  • LIPUS可无创改善肥胖相关肝脂肪变性及代谢异常。
  • 机制涉及肝脏Piezo1-PI3K/AKT激活和FGF21分泌增加。
  • LIPUS上调ATGL/HSL、下调ACLY/FASN调节脂质代谢。

核心结论

  • LIPUS通过Piezo1介导的肝脏脂质代谢调控和FGF21驱动的脂肪组织棕色化改善肝脂肪变性，为肥胖相关代谢紊乱提供新型无创治疗策略。

研究设计与样本

  • 高脂饮食组和高脂饮食加LIPUS组先接受8周高脂饮食，随后改标准饮食4周；LIPUS组在最后4周每日接受20分钟靶向肝区的LIPUS照射。

临床应用与阅片要点

  • LIPUS作为一种无创物理治疗手段，可能为肥胖相关肝脂肪变性提供新的治疗思路，但尚未在人体验证。
  • 机制上涉及肝脏Piezo1-PI3K/AKT通路和FGF21-FGFR1/KLB-PPAR-γ-PGC-1α-UCP-1通路，可作为未来靶点研究的参考。

局限性

  • 未报告盲法、随机化等具体实验设计细节，存在方法学局限。

以上解读依据论文摘要（全文未开放获取或许可不允许翻译转载）。

英文原文（摘要）· 点击展开

OBJECTIVE: To investigate the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) in ameliorating obesity-induced hepatic steatosis and exploring its underlying mechanisms.

METHODS: Thirty male C57BL/6J mice were divided into normal diet (ND), high-fat diet (HFD), and HFD with LIPUS treated (HFD + LIPUS) groups. The ND group was fed standard diet throughout the 12-wk experimental period. The HFD and HFD + LIPUS groups received high-fat diet for the first 8 wk and were then switched to standard diet for the remaining 4 wk. During the final 4 wk, the HFD + LIPUS group received daily 20-min LIPUS irradiation targeting the hepatic region.

RESULTS: HFD-induced metabolic abnormalities including obesity, dyslipidemia, hepatic dysfunction and steatosis were significantly improved by LIPUS. Molecular analysis showed LIPUS coordinately regulated lipid metabolic enzymes by upregulating ATGL/HSL and downregulating ACLY/FASN in both liver and epididymal white adipose tissue (eWAT). Mechanistically, LIPUS activated hepatic Piezo1-PI3K/AKT signaling while suppressing mTOR phosphorylation. Simultaneously, LIPUS stimulated hepatic FGF21 secretion and activated the FGFR1/KLB-PPAR-γ-PGC-1α-UCP-1 pathway in eWAT.

CONCLUSION: LIPUS ameliorates hepatic steatosis by Piezo1-mediated hepatic lipid metabolic regulation and FGF21-driven adipose tissue browning, providing a novel non-invasive therapeutic strategy for obesity-related metabolic disorders.

来源：Ultrasound Med Biol，查看原文。版权归原作者所有。

引用

  1. Yu J, Cao M, Ma S, et al. Low-intensity Pulsed Ultrasound Ameliorates Obesity-induced Hepatic Lipid Metabolic Disorders. Ultrasound Med Biol. 2026. PMID: 42161691. doi:10.1016/j.ultrasmedbio.2026.03.025
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供执业医师工作参考，不替代临床判断；数值与分级以指南原文为准。