介入放射学会关于膝动脉栓塞治疗症状性膝骨关节炎的立场声明
膝骨关节炎在保守治疗失败与关节置换术之间存在治疗空白，慢性滑膜炎和病理性新生血管形成伴血管周围伤害性神经生长是疼痛的重要机制。膝动脉栓塞作为靶向、保留关节的血管介入手段，直接针对炎症和神经血管成分。本学会立场声明综合现有证据，回顾其生物学原理、临床证据、技术要点、安全性和监管进展。
要点
- 膝动脉栓塞是介入放射科医生实施的靶向、保留关节的血管介入，针对膝骨关节炎的炎症与神经血管机制。
- 慢性滑膜炎和病理性新生血管伴血管周围伤害性神经生长是膝骨关节炎疼痛和外周敏化的重要机制。
- 声明综合了膝动脉栓塞的生物学原理、临床证据、技术考虑、安全性和监管现状。
核心结论
- 膝动脉栓塞作为靶向、保留关节的血管介入，直接针对膝骨关节炎的炎症和神经血管成分，是介入放射科医生可用的治疗选择。
研究设计与样本
- 本文件为介入放射学会的立场声明，综合现有知识库，回顾膝动脉栓塞的生物学原理、临床证据、技术考虑、安全性和监管进展。
临床应用与阅片要点
- 介入放射科医生可依据本立场声明理解膝动脉栓塞的生物学原理、技术考虑和安全概况，用于临床实践和患者沟通。
以上解读依据论文摘要（全文未开放获取或许可不允许翻译转载）。
英文原文（摘要）· 点击展开
Knee osteoarthritis (KOA) is a prevalent musculoskeletal condition characterized by a significant therapeutic gap between the failure of conservative medical therapies and surgical arthroplasty. Contemporary evidence supports a model in which chronic synovitis and pathologic neoangiogenesis, closely coupled to perivascular nociceptive nerve growth, serve as significant contributors of pain and peripheral sensitization in KOA. Genicular artery embolization has emerged as a targeted, joint-preserving vascular intervention performed by interventional radiologists that directly addresses the inflammatory and neurovascular components of KOA. The purpose of this societal-endorsed position statement is to synthesize the current knowledge base for genicular artery embolization and review its biologic rationale, clinical evidence, technical considerations, safety profile, and evolving regulatory landscape.
引用
- Ahmed O, Taslakian B, Okuno Y, et al. Society of Interventional Radiology Position Statement on Genicular Artery Embolization for Symptomatic Knee Osteoarthritis. J Vasc Interv Radiol. 2026. PMID: 42118083. doi:10.1016/j.jvir.2026.108803
供执业医师工作参考，不替代临床判断；数值与分级以指南原文为准。