文献速递胸痛与 ACS

心原性休克中临时机械循环支持的EAPCI/ACVC临床共识更新

Temporary mechanical circulatory support in cardiogenic shock.
PubMed 文献 · Eur Heart J · 2026-10-14

本临床共识由ESC/EAPCI/ACVC更新2020版,基于近期RCT证据重塑心原性休克临时机械循环支持(tMCS)策略。一项RCT显示经皮微轴流泵在STEMI合并CS中降低死亡率,而AMI合并CS常规使用VA-ECMO未改善生存且并发症率更高。共识强调表型驱动选择,整合SCAI/SHARC分级指导设备选择、时机与降阶梯。

要点

  • 微轴流泵可降低STEMI合并CS患者死亡率,但VA-ECMO在AMI合并CS中未改善生存。
  • 依据SCAI和SHARC分级进行表型驱动患者筛选以指导tMCS的启用与撤离。
  • 推荐建立多学科休克团队与区域化中心-辐射网络转运系统。

核心结论

  • 心原性休克临时机械循环支持应根据表型驱动筛选患者,微轴流泵在STEMI合并CS中显效,而常规VA-ECMO未改善急性心梗合并CS生存。

研究设计与样本

  • 本声明为ESC下属EAPCI与ACVC更新的临床共识,在2020版专家共识文件基础上纳入近期随机对照试验证据。

主要发现

  • 一项近期RCT表明,经皮微轴流泵在STEMI合并CS患者队列中获益,提示死亡率下降。
  • AMI合并CS人群常规应用VA-ECMO未能改善生存,且与较高并发症发生率相关。

关键数值与推荐

  • 应纳入SCAI分期和SHARC分类指导设备选择、启用时机、升级与降阶梯。
  • 强调建立多学科休克团队、区域化中心-辐射网络系统和结构化升级与无效治疗判定流程。

临床怎么用

  • 整合当代试验数据与最佳实践以优化高危CS人群结局。

以上解读依据论文摘要(全文未开放获取或许可不允许翻译转载)。

原文

Cardiogenic shock (CS) remains a heterogeneous syndrome associated with persistently high mortality despite advances in temporary mechanical circulatory support. One recent randomized controlled trial suggested a mortality benefit of a percutaneous microaxial flow pump in a cohort of patients with ST-elevation myocardial infarction complicated by CS, whereas routine veno-arterial extracorporeal membrane oxygenation in populations with acute myocardial infarction complicated by CS has not improved survival and is associated with higher complication rates. These findings underscore the importance of phenotype-driven patient selection, incorporating the Society for Cardiovascular Angiography and Interventions (SCAI) and Shock Academic Research Consortium (SHARC) classifications to guide device selection, timing, escalation, and de-escalation. This clinical consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) and the Association for Acute CardioVascular Care (ACVC) of the European Society of Cardiology (ESC) updates the 2020 expert consensus document and provides updated practical guidance based on the recent evidence on the use of temporary mechanical circulatory support in acute myocardial infarction complicated by CS. Emphasis is placed on patient/device selection according to recent evidence, multidisciplinary shock teams, regionalized hub-and-spoke systems, structured protocols for escalation and futility, and the integration of contemporary trial data and best practices to optimize outcomes in this high-risk population.

来源:Eur Heart J,查看原文。版权归原作者所有。

引用

  1. Chieffo, Iannaccone, Hassager, et al. Temporary mechanical circulatory support in cardiogenic shock. Eur Heart J. 2026. PMID: 42870411. doi:10.1093/eurheartj/ehag708

供执业医师工作参考,不替代临床判断;数值与分级以指南原文为准。