空气污染相关代谢谱与后续心衰风险
本研究基于大型前瞻性队列，分析环境空气污染暴露与代谢组学特征的关系，并评估其对心衰风险的影响。结果发现由53种代谢物构成的空气污染相关代谢特征水平升高与心衰发病风险增加相关。中介分析提示这些代谢改变可能部分解释空气污染与心衰之间的关联。
要点
- 空气污染相关代谢特征包含53种代谢物。
- 该代谢特征水平升高与心衰风险增加相关。
- 代谢改变可能部分介导空气污染对心衰的影响。
核心结论
- 空气污染暴露相关的53种代谢物特征与心衰风险增加相关，且可能介导空气污染与心衰的部分关联。
研究设计与样本
- 本研究为大型前瞻性队列研究，基于空气污染暴露与代谢组学数据进行分析。
主要发现
- 较高水平的空气污染相关代谢特征与心衰风险增加相关。
- 中介分析提示代谢改变可能解释空气污染与心衰关联的一部分。
关键数值与推荐
- 识别出由53种代谢物组成的空气污染暴露相关代谢特征。
临床怎么用
- 该代谢特征可能为未来机制研究和临床干预提供线索。
以上解读依据论文摘要（全文未开放获取或许可不允许翻译转载）。
原文
WHAT IS ALREADY KNOWN ON THIS TOPIC Air pollution is associated with increased risk of cardiovascular disease, including heart failure (HF), but the metabolic pathways linking exposure to HF remain poorly defined. Prior studies have identified metabolomic alterations related to pollution, yet evidence specifically connecting these changes to incident HF is limited. WHAT THIS STUDY ADDS This study identifies a 53-metabolite profile associated with ambient air pollution exposure in a large prospective cohort. Higher levels of this metabolic signature were associated with an increased risk of incident HF. Mediation analysis suggests that these metabolic alterations account for a measurable proportion of the association between air pollution and HF. HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY The findings highlight metabolic pathways that may help explain pollution–HF relationships and support future mechanistic research. The identified metabolite profile may have...
引用
- Heart：Air pollution-related metabolic profiles and subsequent heart failure risk
供执业医师工作参考，不替代临床判断；数值与分级以指南原文为准。