2型糖尿病疾病修饰结局：改良德尔菲法核心结局集
[Personal View] Disease modification outcomes in type 2 diabetes: a modified Delphi
RSS 订阅 · The Lancet Diabetes and Endocrinology
针对2型糖尿病管理传统聚焦血糖与心血管风险，而非改变长期病程，且缺乏疾病修饰核心结局集。通过改良德尔菲法（依据COMET指南）制定核心结局集，旨在规范试验设计与干预比较。
要点
- 疾病修饰可能改变2型糖尿病进展与并发症
- 缺乏核心结局集限制试验设计与比较
- 用改良德尔菲法制定核心结局集
核心结论
- 制定了2型糖尿病疾病修饰的核心结局集，以支持长期病程评估。
研究设计与样本
- 改良德尔菲法，依据COMET指南实施。
主要发现
- 2型糖尿病为异质性、进展性慢性病，传统管理侧重血糖和心血管风险。
- 进展和并发症可能可修饰，但核心结局集缺失。
临床怎么用
- 该核心结局集可指导未来试验设计，便于干预比较。
以上解读依据论文摘要（全文未开放获取或许可不允许翻译转载）。
原文
Type 2 diabetes is a heterogeneous, progressive chronic condition for which management has traditionally focused on glycaemic control and cardiovascular risk factors, rather than focusing on altering long-term disease trajectory. Increasing evidence indicates that progression and complications might be modifiable, but the absence of a core outcome set for disease modification limits trial design and intervention comparison. To address this gap, we developed a core outcome set for disease modification in type 2 diabetes through a modified Delphi process conducted according to COMET guidance.
来源：The Lancet Diabetes and Endocrinology，查看原文。版权归原作者所有。
引用
- The Lancet Diabetes and Endocrinology：[Personal View] Disease modification outcomes in type 2 diabetes: a modified Delphi
供执业医师工作参考，不替代临床判断；数值与分级以指南原文为准。