中低收入国家重症医学研究：叙事性综述
本综述探讨中低收入国家（LMICs）及资源匮乏环境中重症监护研究面临的复杂动态，聚焦影响重症服务提供的社会经济、人口与结构性障碍。强调当地相关证据对制定卫生政策和临床指南至关重要，尤其需将高收入国家建议适配至资源受限环境。文章指出需持续投资重症研究以改善危重患者结局。
要点
- LMICs及低资源环境危重症疾病负担不成比例地偏高
- 重症研究受社会经济、人口和结构性障碍限制
- 需将高收入国家建议适配至资源受限环境并持续投资
核心结论
- LMICs重症监护研究受多重障碍制约，须持续投资研究与基础设施以改善健康不平等和危重患者结局
研究设计与样本
- 叙事性综述
- 聚焦LMICs及低资源环境，未报告具体样本量或检索数据库范围
主要发现
- 重症疾病对LMICs影响不成比例，医疗资源和基础设施常有限
- 当地相关证据对制定政策和指导方针至关重要，尤其在适配高收入国家建议时
临床怎么用
- 强调需将高收入国家重症推荐适配至资源受限环境，并基于当地证据指导临床决策
局限性
- 叙事性综述未提供具体数值、阈值或统计分析
以上解读依据论文摘要（全文未开放获取或许可不允许翻译转载）。
原文
Critical illness poses a significant global health challenge, disproportionately affecting low- and middle-income countries (LMICs) and other low-resource settings, where healthcare resources and infrastructure are often limited. This narrative review explores the multifaceted dynamics of critical care research in low-resource settings, focusing on socioeconomic, demographic and structural barriers that impact the delivery of intensive care services and its consequences for clinical research. Research is a cornerstone in addressing these challenges. Locally relevant evidence is crucial for informing healthcare policies and clinical guidelines, particularly in adapting high-income country recommendations to resource-constrained contexts. This review describes research challenges and findings on several fields of critical care in LMICs. It underscores the pressing need for sustained investment in critical care research and infrastructure in LMICs to overcome health disparities and improve outcomes for critically ill patients.
引用
- Thorax：Critical care research in low- and middle-income countries: a narrative review
供执业医师工作参考，不替代临床判断；数值与分级以指南原文为准。