文献速递慢阻肺

GOLD与GLI联合声明:使用肺量计定义气流阻塞并诊断慢阻肺

Joint statement from GOLD/GLI regarding the use of spirometry to define airflow obstruction and diagnose COPD.
PubMed 文献 · Eur Respir J · 2026-04-16

GOLD与GLI就肺量计诊断慢阻肺发表联合声明,认同在合适临床背景下可用固定比值识别慢阻肺相关气流阻塞,并关注肺量计使用不足与误诊漏诊问题,旨在结束关于阈值的长久争论。

要点

  • 在合适临床背景下,固定比值可用于识别慢阻肺相关气流阻塞。
  • 肺量计全球可及性有限、使用不足,导致误诊和漏诊。
  • 联合声明旨在结束关于气流阻塞定义阈值的长久争论。

核心结论

  • GOLD与GLI认同在合适临床背景下可用固定比值识别慢阻肺相关气流阻塞。

研究设计与样本

  • 本文为GOLD与GLI联合声明(观点文章),未报告系统检索或样本量。

主要发现

  • 肺量计全球可及性有限且使用不足,许多人被误诊或漏诊。
  • FEV1/FVC比值降低可显示呼气气流受限。
  • 关于定义气流阻塞的阈值已争论超过30年。

关键数值与推荐

  • 在合适临床背景下,固定比值可用于识别慢阻肺相关气流阻塞。

临床怎么用

  • 在合适临床背景下使用肺量计确认或排除慢阻肺诊断。

以上解读依据论文摘要(全文未开放获取或许可不允许翻译转载)。

原文

GOLD and GLI agree on many important issues regarding diagnosing COPD with spirometry, sharing concerns about under-use and agreeing that, in the appropriate clinical context, the fixed ratio can be used to identify COPD-related airflow obstruction https://bit.ly/4tB8cZt COPD is one of the leading causes of morbidity and mortality worldwide [1]. Spirometry provides an objective measure of airflow obstruction that, in the appropriate clinical context, confirms the diagnosis of COPD. However, globally, access to spirometry is limited, the test is under-utilised, and many people are either misdiagnosed [2] or under-diagnosed [3, 4]. The intrathoracic airway obstruction that characterises COPD can be detected by finding expiratory flow limitation on spirometry. A reduced forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio demonstrates flow limitation, but for more than 30 years there has been an unproductive debate about which threshold should be used to define airflow limitation and identify airway obstruction in patients with suspected COPD. In this viewpoint article, we focus on the use of spirometry use in routine clinical practice to confirm or exclude a diagnosis of COPD, and aim to propose a way forward to end the debate.

来源:Eur Respir J,查看原文。版权归原作者所有。

引用

  1. Halpin DMG, Stanojevic S, McCormack MC, et al. Joint statement from GOLD/GLI regarding the use of spirometry to define airflow obstruction and diagnose COPD. Eur Respir J. 2026. PMID: 41748283. doi:10.1183/13993003.02574-2025

供执业医师工作参考,不替代临床判断;数值与分级以指南原文为准。