经阴道自然腔道内镜手术行腹膜后前哨淋巴结清扫术治疗早期宫颈癌一例
本文报道一例56岁宫颈腺癌患者,术前MRI提示左侧盆腔淋巴结可疑转移(约1 cm),采用vNOTES经阴道腹膜后路径行前哨淋巴结活检,使用异硫蓝染料注射宫颈,分7步完成手术,认为该术式对选择性早期宫颈癌患者可行,可避免腹部切口并辅助个体化治疗决策。
要点
- vNOTES腹膜后前哨淋巴结活检在早期宫颈癌中技术可行
- 术前可疑淋巴结者可行前哨淋巴结取样指导治疗决策
- 无吲哚菁绿时可用异硫蓝2 mL分深浅层注射宫颈
核心结论
- vNOTES腹膜后前哨淋巴结清扫在选择性早期宫颈癌患者中作为微创淋巴结评估方法可行。
- 该术式可能支持个体化治疗规划并避免腹部入路。
研究设计与样本
- 病例报告(视频摘要),报道1例56岁宫颈腺癌患者。
- 术前MRI提示左侧盆腔淋巴结可疑转移,大小约1 cm。
- 手术采用vNOTES经阴道腹膜后路径行前哨淋巴结活检,分7个步骤完成。
主要发现
- 术前可疑淋巴结可能改变治疗计划,故在根治术前行前哨淋巴结取样。
- 使用异硫蓝2 mL(3点和9点位置各注射0.5 mL浅层和0.5 mL深层)进行宫颈注射。
- 手术步骤包括宫颈蓝染注射、经阴道侧穹窿进入腹膜后间隙、腹膜后分离、解剖标志识别、前哨淋巴结检测、闭孔窝分离及前哨淋巴结切除。
关键数值与推荐
- 前哨淋巴结活检已成为淋巴结评估的微创可靠方法。
- 早期宫颈癌中确认淋巴结受累可将处理从原发手术改为放化疗。
- 吲哚菁绿可能提供更高检出率,但本机构未具备,故使用异硫蓝。
临床怎么用
- 对早期宫颈癌伴影像学可疑淋巴结者,可考虑vNOTES腹膜后前哨淋巴结活检以指导治疗决策。
- 手术中应注重解剖标志识别和腹膜后路径的逐步分离。
- 染料选择需根据机构可用性决定,吲哚菁绿优先但异硫蓝可替代。
局限性
- 单例病例报告,结论的普遍适用性有限。
- 无长期随访或结局数据报告。
- 未提供前哨淋巴结检出率或假阴性率等数值。
以上解读依据论文摘要(全文未开放获取或许可不允许翻译转载)。
原文
OBJECTIVE: To demonstrate retroperitoneal sentinel lymph node dissection for early-stage cervical cancer using vaginal natural orifice transluminal endoscopic surgery (vNOTES). SETTING: Lymph node status plays a central role in staging and treatment planning in cervical cancer [1]. In early-stage disease, confirmation of nodal involvement may alter management from primary surgery to chemoradiotherapy [2]. Sentinel lymph node biopsy has emerged as a minimally invasive and reliable method for nodal assessment [3]. This video article demonstrates retroperitoneal sentinel lymph node dissection via vNOTES in 7 surgical steps. PARTICIPANTS: About 56-year-old woman with cervical adenocarcinoma INTERVENTIONS: We present the case of a 56-year-old woman with cervical adenocarcinoma and a radiologically suspicious left pelvic lymph node measuring approximately 1 cm on preoperative magnetic resonance imaging. Because suspected nodal involvement would directly influence treatment planning, sentinel lymph node sampling was performed before definitive surgery. To improve orientation for viewers, the text includes a literal drawing of the pelvic retroperitoneal pathway and the expected location of the sentinel lymph node, together with expanded narration emphasizing key anatomic landmarks and dissection steps (Fig. 1). Although indocyanine green may provide higher detection rates, isosulfan blue was used because indocyanine green was not available at our institution. A total of 2 mL of undiluted isosulfan blue was injected into the cervix at the 3 and 9 o'clock positions, with 0.5 mL injected superficially and 0.5 mL deeply at each site. The procedure consisted of: (1) cervical blue dye injection; (2) entry into the retroperitoneal space through the lateral vaginal fornix; (3) retroperitoneal dissection; (4) identification of anatomic landmarks; (5) detection of the sentinel lymph node; (6) obturator fossa dissection; and (7) sentinel lymph node excision. CONCLUSION: Retroperitoneal sentinel lymph node dissection using vNOTES appears feasible as a minimally invasive approach for nodal assessment in selected patients with early-stage cervical cancer and may support individualized treatment planning while avoiding abdominal access. VIDEO ABSTRACT.
引用
- Ilgen O, Karatasli V. Retroperitoneal Sentinel Lymph Node Dissection Using vNOTES in Early-Stage Cervical Cancer: A Case Report. J Minim Invasive Gynecol. 2026. PMID: 42173355. doi:10.1016/j.jmig.2026.05.012
供执业医师工作参考,不替代临床判断;数值与分级以指南原文为准。