光生物调节对儿童口腔软组织局部麻醉恢复的影响：一项初步的分裂口随机临床试验。
完整摘要 · 中文译文
儿科牙科患者在局部麻醉（LA）后尤其容易发生意外软组织损伤。这项初步研究评估了810纳米二极管激光光生物调节（PBM）在逆转儿科患者口腔软组织麻醉中的临床疗效。根据伦理规范，纳入了34名8-12岁需要在浸润性局部麻醉下进行双侧乳牙拔除的儿童。按照局部浸润麻醉方案，使用含1:80,000肾上腺素的2%利多卡因实施局部麻醉。参与者被随机分配接受PBM和假激光治疗，两次干预之间设有7-10天的洗脱期。PBM使用810纳米二极管激光以连续模式、200毫瓦功率、每个点12秒的参数，在六个预先确定的口内和口外位点进行照射。一名独立检查者通过标准化双侧触诊，以未麻醉侧作为参照，每隔5分钟评估软组织感觉。主要结局指标为麻醉侧感觉被判定为正常时的首次评估时间。数据采用配对样本t检验进行分析。PBM组的平均恢复时间（60.7 ± 27.3分钟；p < 0.001）显著短于假激光组（78.2 ± 17.0分钟）。亚组分析显示上颌弓和下颌弓的恢复时间均显著缩短。使用810纳米二极管激光的光生物调节显示，在儿科患者浸润性局部麻醉后，主观软组织麻醉恢复时间有所缩短。 在测试条件下接受治疗的儿科牙科患者。
完整摘要 · 英文原文
Paediatric dental patients are particularly vulnerable to inadvertent soft-tissue injury following local anaesthesia (LA) This preliminary study evaluated. the clinical efficacy of 810-nm diode laser photobiomodulation (PBM) in reversing oral soft-tissue anaesthesia in paediatric patients. Thirty-four children aged 8-12 years requiring bilateral primary toothextractions under infiltration LA were enrolled in by consideration of ethical codes. Local anaesthesia was administered using 2% lidocaine with 1:80,000 epinephrine, as per the local infiltration anesthesia protocol. Participants were randomly allocated to receive both PBM and sham Laser with 7-10 days washout period between the two interventions. PBM was delivered using an 810-nm diode laser in continuous mode at 200 mW for 12 s per point at six predefined intraoral and extraoral sites. An independent examiner assessed soft-tissue sensation at 5-minute intervals by standardized bilateral palpation, using the non-anaesthetized side as the reference. The primary outcome was time to first assessment at which sensation on the anaesthetized side was judged normal. Data were analysed using a paired-samples t-test. Mean reflection time was significantly shorter in the PBM group (60.7 ± 27.3 min; p < 0.001) compared with the Sham lasergroup (78.2 ± 17.0 min). Subgroup analysis demonstrated significant reductions in reflection time in both maxillary and mandibular arches. Photobiomodulation using an 810-nm diode laser demonstrated a reduction in subjective soft tissue anaesthesia recovery time following infiltration LA in paediatric dental patients under the conditions tested.