科研动态期刊摘要
ALS中持续且区室化的T细胞免疫
Nature Medicine · 2026-10-28
摘要
《自然·医学》,在线发表:2026年10月27日;doi:10.1038/s41591-026-04728-5 在肌萎缩侧索硬化(ALS)中,持续的T细胞反应与疾病结局的关联在血液和脑脊液中有所不同,其中鞘内抗原呈递和巨细胞病毒特异性免疫均与较差的临床结局相关。
English
Persistent and compartmentalized T cell immunity in ALS
Nature Medicine, Published online: 27 October 2026; doi:10.1038/s41591-026-04728-5 In ALS, persistent T cell responses relate to disease outcome differently in blood than in cerebrospinal fluid, with both intrathecal antigen presentation and cytomegalovirus-specific immunity linked to worse clinical outcomes.