幽门螺杆菌感染——进展、挑战与未来之路
完整摘要 · 中文译文
幽门螺杆菌的发现彻底变革了胃炎、消化性溃疡以及最为重要的胃癌的预防和治疗。在过去40年中，幽门螺杆菌感染的临床和基础研究取得了巨大进展。然而，由于缺乏幽门螺杆菌疫苗以及全球范围内抗生素耐药性不断增加，幽门螺杆菌感染的预防和治疗仍面临挑战。本综述总结了幽门螺杆菌研究的历史和关键里程碑，介绍了幽门螺杆菌感染发病机制和全球负担以及胃癌一级预防筛查策略的最新认识，并重点关注幽门螺杆菌感染管理的新趋势。
完整摘要 · 英文原文
The discovery of Helicobacter pylori has revolutionized the prevention and treatment of gastritis, peptic ulcers, and, most important, gastric cancer. In the past 40 years, enormous progress has been achieved in the clinical and basic research on H. pylori infection. However, challenges in preventing and treating H. pylori infection exist owing to the lack of an H. pylori vaccine and the ever-increasing resistance to antibiotics worldwide. This review summarizes the history of and key milestones in H. pylori research, provides an update on the understanding of the pathogenesis and global burden of H. pylori infection and the screening strategy for the primary prevention of gastric cancer, and focuses on the emerging trends in the management of H. pylori infection.