全食物蛋白质来源在运动后状态下对餐后血浆双亮氨酸谱产生差异性调节。
完整摘要 · 中文译文
二亮氨酸是一种含亮氨酸的二肽，可能比单独使用亮氨酸更能增强合成代谢信号。本研究考察了摄入动物性和植物性全食物后餐后血浆二亮氨酸和亮氨酸浓度，及其与肌肉蛋白合成率（MPS）的关系。对来自两项随机对照试验共26名健康成人（25 ± 4.3岁）的血浆样本进行了二次分析。受试者分别摄入低脂猪肉（LFP）、高脂猪肉末（HFP）、互补米饭和豆类（COMP）、等氮混合营养饮料（ISO）或碳水化合物对照（CHO）。测量了血浆浓度和MPS。血浆二亮氨酸仅在摄入LFP后显著升高（p < 0.05），其300分钟iAUC大于CHO（p = 0.038）。除COMP和CHO外，所有条件下血浆亮氨酸均升高，其中LFP表现出最高浓度（p < 0.05）。观察到二亮氨酸Cmax与MPS变化（ΔMPS）之间存在中等相关性（r = 0.436，p = 0.037），而亮氨酸Cmax无显著关联（r = 0.265，p = 0.102）。全食物蛋白质来源通常不会升高血浆二亮氨酸，LFP除外。虽然二亮氨酸Cmax与ΔMPS相关，但这种关系的强度提示二亮氨酸可能只是除游离亮氨酸外影响MPS的若干餐后因素之一。
完整摘要 · 英文原文
Dileucine, a leucine-containing dipeptide, may enhance anabolic signaling more than leucine alone. This study examined postprandial plasma dileucine and leucine concentrations after ingesting animal- and plant- whole foods and their association with muscle protein synthesis rates (MPS). Secondary analysis was performed on plasma samples collected from two randomized controlled trials totaling 26 healthy adults (25 ± 4.3 y). Participants consumed low-fat pork (LFP), high-fat ground pork (HFP), complementary rice and beans (COMP), an iso-nitrogenous mixed nutrient beverage (ISO), or a carbohydrate control (CHO). Plasma concentrations and MPS was measured. Plasma dileucine increased significantly only after LFP ingestion (p < 0.05), with a greater 300-min iAUC compared to CHO (p = 0.038). Plasma leucine increased in all conditions except COMP and CHO with LFP demonstrating the highest concentrations (p < 0.05). A modest correlation was observed between dileucine Cmax and the change in MPS (ΔMPS; r = 0.436, p = 0.037), whereas leucine Cmax showed no significant association (r = 0.265, p = 0.102). Whole-food protein sources generally do not elevate plasma dileucine, except for LFP. While dileucine Cmax correlated with ΔMPS, the strength of this relationship suggests dileucine is likely one of several postprandial factors influencing MPS beyond free leucine.