三种传统中成药联合经动脉化疗栓塞术治疗原发性肝癌：系统评价与贝叶斯网状荟萃分析。
完整摘要 · 中文译文
背景：采用贝叶斯网状Meta分析评估3种中成药（复方斑蝥胶囊、槐耳颗粒、金龙胶囊）联合肝动脉化疗栓塞术（TACE）治疗原发性肝癌的客观缓解率（ORR）和疾病控制率。 方法：系统检索Cochrane Library、Embase、PubMed、Web of Science、维普中文科技期刊数据库、中国知网和万方数据库，检索时间从建库至2025年1月10日，纳入随机对照试验（RCT）。两名研究者按照预先设定的纳入和排除标准独立筛选文献、提取数据并评价研究质量。使用RStudio进行贝叶斯网状Meta分析，对纳入RCT中的干预措施按效应量进行综合和分层排序。本综述已在PROSPERO注册（CRD420251019361）。 结果：共纳入31项RCT，涉及2604例原发性肝癌患者。网状Meta分析显示，与单独TACE相比：复方斑蝥胶囊在客观缓解率方面排名最高（OR = 1.50，95% CI：1.08，2.08），其次是槐耳颗粒（OR = 1.47，95% CI：1.05，2.05）和金龙胶囊（OR = 1.30，95% CI：1.02，1.65）。在疾病控制率方面，排名为复方斑蝥胶囊（OR = 1.21，95% CI：0.76，1.93）、金龙胶囊（OR = 1.17，95% CI：0.85，1.59）和槐耳颗粒（OR = 1.12，95% CI：0.66，1.91）。 结论：在客观缓解率方面，3种中成药联合TACE的疗效优于单独TACE。 未治疗组，其中复方斑蝥胶囊在评估的干预措施中显示出最大的治疗潜力。
完整摘要 · 英文原文
BACKGROUND: To evaluate the objective response rate (ORR) and disease control rate of 3 Chinese herbal medicines (Compound Banmao Capsule, Huaier Granule, and Jinlong Capsule) combined with transarterial chemoembolization (TACE) for primary liver cancer using Bayesian network meta-analysis. METHODS: We systematically searched randomized controlled trials (RCTs) across the Cochrane Library, Embase, PubMed, Web of Science, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang databases from their inception to January 10, 2025. Two researchers independently screened the literature, extracted data, and assessed study quality using predefined inclusion and exclusion criteria. A Bayesian network meta-analysis was performed using RStudio to synthesize and hierarchically rank interventions by effect size in the included RCTs. This review was registered with PROSPERO (CRD420251019361). RESULTS: Thirty-one RCTs involving 2604 patients with primary liver cancer were included. The network meta-analysis showed that, compared with TACE alone: Compound Banmao Capsule ranked highest for ORR (OR = 1.50, 95% CI: 1.08, 2.08), followed by Huaier Granule (OR = 1.47, 95% CI: 1.05, 2.05) and Jinlong Capsule (OR = 1.30, 95% CI: 1.02, 1.65). For disease control rate, the ranking was Compound Banmao Capsule (OR = 1.21, 95% CI: 0.76, 1.93), Jinlong Capsule (OR = 1.17, 95% CI: 0.85, 1.59), and Huaier Granule (OR = 1.12, 95% CI: 0.66, 1.91). CONCLUSION: For ORR, the combination of the 3 Chinese herbal medicines with TACE showed superior efficacy to TACE monotherapy, with Compound Banmao Capsule demonstrating the greatest therapeutic potential among the interventions evaluated.