妄想的脑网络定位。
完整摘要 · 中文译文
背景：妄想是精神分裂症谱系障碍的一种跨诊断核心症状，并与不良功能结局相关。尽管近期有大量工作成功地将神经精神症状映射到特定脑网络，但针对妄想网络定位的研究仍然很少。 方法：我们首先对44项已发表的神经影像学研究进行了系统性回顾，以识别与妄想相关的结构和功能改变的脑区。通过将功能连接网络映射应用于来自两个独立静息态功能磁共振成像数据集的规范性功能连接组，我们将这些受影响脑区映射至三个妄想网络。 结果：妄想形态异常网络与任务诱导激活异常网络均广泛分布且具有一定的空间相似性。除了与腹侧注意网络和躯体运动网络存在共享的空间重叠外，妄想形态异常网络与前顶叶网络和背侧注意网络表现出更大的空间重叠，而任务诱导激活异常网络则与皮层下网络和边缘网络重叠更为广泛。同时，妄想静息态活动异常网络与默认网络表现出最大的空间重叠。此外，右侧岛盖部额下回、右侧前无颗粒岛叶复合体及右侧颞上回前部表现出功能连接... 与这些妄想网络概率图具有最高空间相似性的区域，因此被认为是潜在的神经调控靶点。 结论：除了从网络视角阐明妄想背后的神经生物学机制外，我们的发现还可能为开发可靠的生物标志物和针对妄想的靶向治疗提供参考。
完整摘要 · 英文原文
BACKGROUND: Delusions constitute a cross-diagnostic core symptom of schizophrenia spectrum disorders and correlate with poor functional outcomes. Despite much recent effort successfully mapping neuropsychiatric symptoms to specific brain networks, investigations focusing on network localization of delusions are still scarce. METHODS: We initially conducted a systematic review of 44 published neuroimaging studies to identify brain regions exhibiting structural and functional alterations associated with delusions. By applying functional connectivity network mapping to normative functional connectomes derived from two independent resting-state functional magnetic resonance imaging datasets, we mapped these affected brain regions to three delusion networks. RESULTS: The delusion morphology and task-induced activation abnormality networks were both broadly distributed and had some spatial similarities. In addition to their shared spatial overlap with the ventral attention and somatomotor networks, the delusion morphology abnormality network showed greater spatial overlap with the frontoparietal and dorsal attention networks, while the task-induced activation abnormality network overlapped more extensively with the subcortical and limbic networks. Concurrently, the delusion resting-state activity abnormality network showed the greatest spatial overlap with the default network. In addition, the right opercular part of the inferior frontal gyrus, the right anterior agranular insula complex, and the right anterior portion of the superior temporal gyrus exhibited functional connectivity profiles with the highest spatial similarity to these delusion network probability maps and were therefore considered potential neuromodulation targets. CONCLUSIONS: Aside from elucidating the neurobiological mechanism underlying delusions from a network perspective, our findings potentially inform the development of reliable biomarkers and targeted treatments for delusions.