正念疗法对复发性流产女性压力生物标志物和心理症状的影响：一项随机临床试验。
完整摘要 · 中文译文
复发性流产（RPL）女性表现出高水平的抑郁、焦虑和压力，这些对其生活质量产生负面影响。这项随机临床试验评估了为期八周、每周一次一小时课程的在线基于正念的干预（MBI）对35名RPL女性心理和生物压力标志物的影响。参与者被随机分配至MBI组或标准护理组（对照组），并在干预前后通过唾液生物标志物（皮质醇、α-淀粉酶和免疫球蛋白A（IgA））以及经过验证的问卷——抑郁-焦虑-压力量表-21（DASS-21）和心理健康总体幸福感指数（PGWB-I）进行评估。在唾液生物标志物中未观察到显著的时间×组交互作用，包括皮质醇（p = 0.672）、α-淀粉酶（p = 0.342）和IgA（p = 0.148）。MBI组参与者的DASS-21总分（p = 0.018）、抑郁（p = 0.026）和压力（p = 0.015）评分显著降低，而焦虑评分在两组之间无显著差异（p = 0.121）。他们还表现出总体幸福感（p < 0.001）和多个PGWB-I维度的显著改善。这些发现表明，MBI可能改善RPL女性的自我报告心理幸福感；然而，由于在主要生物标志物结局中未观察到显著影响，这些次要心理发现应被视为探索性和假设生成性的。试验注册：https://ensaiosclinicos.gov.br/rg/RBR-4xc76cr。
完整摘要 · 英文原文
Women with recurrent pregnancy loss (RPL) exhibit high levels of depression, anxiety, and stress, which negatively impact their quality of life. This randomized clinical trial evaluated the effects of an eight-week online Mindfulness-Based Intervention (MBI), with weekly one-hour sessions, on psychological and biological markers of stress in 35 women with RPL. Participants were randomly assigned to either the MBI or standard care (control group) and assessed before and after the intervention through salivary biomarkers (cortisol, alpha-amylase, and Immunoglobulin A-IgA) and the validated questionnaires Depression, Anxiety and Stress Scale-21 (DASS-21) and Psychological General Well-Being Index (PGWB-I). No significant time × group interactions were observed for salivary biomarkers, including cortisol (p = 0.672), alpha-amylase (p = 0.342), and IgA (p = 0.148). Participants in the MBI group showed significant reductions in total DASS-21 (p = 0.018), depression (p = 0.026), and stress (p = 0.015) scores, whereas anxiety did not differ significantly between groups (p = 0.121). They also showed robust improvements in overall well-being (p < 0.001) and multiple PGWB-I domains. These findings suggest that MBI may improve self-reported psychological well-being in women with RPL; however, as no significant effects were observed in the primary biomarker outcomes, these secondary psychological findings should be considered exploratory and hypothesis-generating. TRIAL REGISTRATION: https://ensaiosclinicos.gov.br/rg/RBR-4xc76cr.