CTLA4 +49A/G 多态性与儿童哮喘易感性的关联：一项荟萃分析。
完整摘要 · 中文译文
通过荟萃分析探讨细胞毒性T淋巴细胞相关抗原4（CTLA-4）+49A/G位点单核苷酸多态性（SNP）与儿童哮喘风险之间的关联。检索了六个数据库，查找关于CTLA-4 +49A/G位点多态性与儿童哮喘相关性的记录。检索时间自各数据库建库至2024年7月。应用Stata 15.0软件，计算合并OR及95% CI。分析五种遗传模型（G/A、GA+AA/AA、G/GA+AA、GG/AA和GA/AA）。共纳入9项研究，包括2133例病例和1572名对照。合并结果显示，在等位基因（OR, 0.53; 95% CI, 0.35-0.79）、显性（OR, 0.41; 95% CI, 0.24-0.71）、隐性（OR, 0.60; 95% CI, 0.41-0.89）、纯合（OR, 0.38; 95% CI, 0.22-0.68）和杂合（OR, 0.52; 95% CI, 0.33-0.80）模型下，差异均有统计学意义。荟萃分析表明，CTLA-4 +49A/G SNP与儿童哮喘易感性相关，等位基因G以及基因型GG+GA、GG和GA与哮喘风险降低相关。
完整摘要 · 英文原文
To investigate the association between single nucleotide polymorphism (SNP) of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) +49A/G locus and the risk of asthma in children by meta-analysis. Six databases were searched for records on the association between CTLA-4 +49A/G locus polymorphism and pediatric asthma. The retrieval time was from the establishment of each database to July 2024. Stata 15.0 software was applied, with the pooled OR and 95% CI calculated. Five genetic models (G/A, GA+AA/AA, G/GA+AA, GG/AA, and GA/AA) were analyzed. Nine studies were included, covering 2133 Cases and 1572 controls. The combined results exhibited that the differences were all statistically significant under the allelic (OR, 0.53; 95% CI, 0.35-0.79), dominant (OR, 0.41; 95% CI, 0.24-0.71), recessive(OR, 0.60; 95% CI, 0.41-0.89), homozygous (OR, 0.38; 95% CI, 0.22-0.68) and heterozygous (OR, 0.52; 95% CI, 0.33-0.80) models. The meta-analysis indicates that CTLA-4 +49A/G SNP is related to susceptibility to pediatric asthma, and allele G and genotype GG+GA, GG, and GA correlated with a decreased risk of asthma.