创伤性中枢神经系统损伤后小胶质细胞和神经元中的PANoptosis：病理特征与治疗意义的系统综述。
摘要
背景：创伤性脑损伤（TBI）和脊髓损伤（SCI）可诱导PANoptosis，这是一种由PANoptosome编排的促炎性程序性细胞死亡方式。该方式整合了焦亡、凋亡和坏死性凋亡的分子机制，与经典的单一通路细胞死亡形成对比。方法：本系统综述（PROSPERO CRD420261383435）遵循PRISMA，并检索了PubMed、Web of Science和Cochrane Library。…
正文 待译
BACKGROUND: Traumatic brain injury (TBI) and spinal cord injury (SCI) induce PANoptosis, a pro-inflammatory programmed cell death modality orchestrated by the PANoptosome. This modality integrates pyroptosis, apoptosis, and necroptosis molecular machinery and contrasts with canonical single-pathway cell death. METHODS: This systematic review (PROSPERO CRD420261383435) followed PRISMA and searched PubMed, Web of Science, and Cochrane Library. The in vivo studies confirming PANoptosis at the protein level were included; quality was assessed using CRIME-Q, and shared genes/protein interactions were analyzed via GeneCards, STRING, and Cytoscape. RESULTS: Ten studies (five TBI and five SCI) were included. PANoptosis occurs in microglia and neurons, with significant crosstalk in secondary injury. Regulatory mechanisms included transcriptional regulation, inflammatory signaling, ubiquitination, energy metabolism, proteolysis, and mitophagy. Interventions comprised specific inhibitors, Chinese medicine formula granules, small molecules, siRNAs, drugs, metabolites, plasmids, and metal ions. Key sensors included ZBP1 and NLRP12, with ASC as the main adaptor; executioners included CASP1, GSDMD, CASP3/8, RIPK1/3, MLKL, and activated forms. Ischemia was the most significant disease-gene network factor. CONCLUSION: The primary injury activates microglia and neurons, inducing PANoptosis via multiple pathways; targeting PANoptosome assembly may preserve immuno-inflammatory balance and limit secondary damage. Future research should prioritize comprehensive PANoptosome detection, standardized animal models, CNS cell interactions, novel drug delivery, and ischemia-reperfusion injury.
English
BACKGROUND: Traumatic brain injury (TBI) and spinal cord injury (SCI) induce PANoptosis, a pro-inflammatory programmed cell death modality orchestrated by the PANoptosome. This modality integrates pyroptosis, apoptosis, and necroptosis molecular machinery and contrasts with canonical single-pathway cell death. METHODS: This systematic review (PROSPERO CRD420261383435) followed PRISMA and searched PubMed, Web of Science, and Cochrane Library.…