与人类和节肢动物媒介中虫媒传染病相关的微小RNA反应：一项系统综述。
完整摘要 · 中文译文
媒介传播疾病（VBDs）构成重大的公共卫生挑战。早期且准确的诊断对于有效的疾病管理和控制至关重要，宿主编码的微小RNA（miRNA）正成为有前景的疾病生物标志物。本系统综述调查了针对VBD的疾病媒介和人类宿主中miRNA反应所开展的研究。对四个数据库的系统检索及人工检索共识别出93篇合格文章。文献描述了众多VBD，其中最常关注的是登革热（21%；n = 15）和恰加斯病（11%；n = 8）。28项体内人体研究对与VBD相关的miRNA进行了特征描述，涉及的疾病包括非洲锥虫病、恰加斯病、克里米亚-刚果出血热、登革热、日本脑炎、利什曼病、疟疾、盘尾丝虫病、血吸虫病和寨卡病毒病。在恰加斯病（miR-208a）、登革热（miR-146-5p）和血吸虫病（sma-miR-bantam）中观察到miRNA对感染的反应存在一定重叠，而大多数则表现出极少的重叠。针对节肢动物媒介miRNA谱的研究主要集中于蜱类，许多工作聚焦于蜱唾液、唾液腺、若虫期蜱和成蜱的miRNA谱，因为它们在病原体传播中发挥关键作用。本综述报告了 investigating 人类VBD诊断和预后miRNA生物标志物的研究极为匮乏，并提出制定标准化方案及在多个研究队列中进行验证作为未来方向。
完整摘要 · 英文原文
Vector-borne diseases (VBDs) represent a significant public health challenge. Early and accurate diagnosis is crucial for effective disease management and control, with host-encoded microRNAs (miRNAs) emerging as promising disease biomarkers. This systematic review surveys research conducted on miRNA responses in disease vectors and human hosts of VBDs. A systematic search of four databases and manual searching identified 93 qualifying articles. Numerous VBDs were described, with the most common focus on dengue (21%; n = 15) and Chagas disease (11%; n = 8). Twenty-eight in vivo human studies have characterised miRNAs linked to VBDs, including African trypanosomiasis, Chagas disease, Crimean-Congo haemorrhagic fever, dengue, Japanese encephalitis, leishmaniasis, malaria, onchocerciasis, schistosomiasis, and Zika virus disease. Some overlaps of miRNA responses to infection were observed for Chagas disease (miR-208a), dengue (miR-146-5p), and schistosomiasis (sma-miR-bantam), while the majority exhibited minimal overlap. Studies addressing miRNA profiling of arthropod vectors predominantly emphasise ticks, with many efforts focusing on the miRNA profiles of tick saliva, salivary glands, nymphal ticks, and adults due to their pivotal role in pathogen transmission. This review reports a paucity of studies investigating miRNA biomarkers for VBD diagnosis and prognosis in humans and nominates the development of standardised protocols and validation across study cohorts as future directions.