音频-本体-发声强化训练对主观性耳鸣的神经调控效应，一项高密度脑电图（HD-EEG）研究方案。
完整摘要 · 中文译文
耳鸣影响全球14%的人口，其中2%经历该病症的严重形式。使用助听器发出的白噪声进行声音治疗是一种常见干预手段，其依据是在耳鸣评估中观察到的残余抑制现象。本研究旨在探究音频-本体-发声强化训练能否通过使患者聆听自身发声来改善慢性主观性耳鸣患者的生活质量，这种聆听可能掩蔽耳鸣或诱导残余抑制。我们将开展一项前瞻性、对照、单中心、2臂区组随机研究，按耳鸣残疾量表（THI）评分进行分层，涉及两组并分为两个连续阶段（第1阶段和第2阶段）。从奥尔良大学医院耳鼻喉（ENT）科招募的56名耳鸣患者将接受为期五周的训练项目，随机分为每周远程小组工作坊和每日使用专门开发视频的个体训练课程。训练效果将通过自评问卷进行评估。主要终点即耳鸣残疾量表将在三次耳鼻喉科医学访视时进行评估：入组时、第1阶段结束时和第2阶段结束时。此外，两组患者将在整个研究期间通过安全数字平台定期完成耳鸣视觉模拟量表及五个相关问题（噪声、颈部、颌部、睡眠、压力-焦虑）。高密度脑电图（HD-EEG）将在第1阶段前后以盲法在神经内科进行 奥尔良大学医院科室。本初步研究旨在评估音频-本体感觉-发声训练对慢性主观性耳鸣患者的临床疗效，并使用高清脑电图（HD-EEG）客观测量其效果。我们将探索大脑活动变化（如功能性脑连接）与干预临床反应之间的潜在相关性。
完整摘要 · 英文原文
Tinnitus affects 14% of the global population, with 2% experiencing a severe form of the condition. Sound therapy using white noise emitted by hearing aids is a common intervention, supported by the phenomenon of residual inhibition observed during tinnitus assessment. This study aims to investigate whether audio-proprio-phonatory reinforcement training can improve the quality of life of patients with chronic subjective tinnitus by enabling them to listen to their own phonation, which may mask the tinnitus or induce residual inhibition. We will conduct a prospective, controlled, monocentric, 2-arm block-randomized study, stratified by the Tinnitus Handicap Inventory (THI) score, involving two groups for two sequential phases (Phase 1 and Phase 2). Fifty-six patients with tinnitus, recruited from the Ear Nose Throat (ENT) Department of Orléans University Hospital, will undergo a five-week training program, randomized into weekly remote group workshops, and daily individual sessions using specially developed videos. Training efficacy will be assessed through self-report questionnaires. The primary endpoint, the Tinnitus Handicap Inventory, will be assessed at three ENT medical visits: at inclusion, end of phase 1 and end of phase 2. Additionally, patients in both groups will regularly complete Visual Analog Scales for Tinnitus and five related questions (noise, cervical, jaw, sleep, stress-anxiety) via a secure digital platform throughout the study. High-density electroencephalograms (HD-EEG) will be performed in a blinded manner before and after Phase 1 at the Neurology Department of Orléans University Hospital. This pilot study aims to evaluate the clinical efficacy of audio-proprio-phonatory training in patients with chronic subjective tinnitus and to objectively measure its effects using HD-EEG. We will explore potential correlations between changes brain activity (such as functional brain connectivity) and clinical responses to the intervention.