Additive effects of active vitamin D3 or vitamin E administration on therapeutic lower-limb home exercise for knee osteoarthritis: A pilot prospective randomized controlled trial.
完整摘要 · 中文译文
背景：股四头肌无力、炎症和身体功能下降在膝骨关节炎（OA）中较为常见，下肢运动疗法是一种已确立的非药物治疗方法。维生素D3（vit D3）和维生素E（vit E）曾被 proposed 作为辅助治疗；然而，临床研究结果并不一致。我们旨在探讨在有症状的膝骨关节炎女性中，将下肢家庭运动与口服活性维生素D3或维生素E补充联合使用，与单纯家庭运动相比是否能提供额外获益。 方法：88名绝经后膝骨关节炎女性（Kellgren-Lawrence分级2-4级；71.9 ± 5.6岁）被随机分配至仅接受治疗性下肢家庭运动组、家庭运动联合活性维生素D3给药组或家庭运动联合维生素E给药组。参与者每日进行两次下肢等长运动，持续24周。随后，采用日本膝骨关节炎测量量表（JKOM）作为主要结局进行评估。次要结局为简短健康调查、握力、股四头肌肌力、10米步行试验、炎症标志物、骨密度和身体成分。数据分析采用配对和独立t检验、方差分析及协方差分析，并校正年龄、体质指数和Kellgren-Lawrence分级。 结果：80名参与者完成了随访。所有组的JKOM评分、股四头肌肌力和10米步行试验均显示显著改善。握力仅在接受活性维生素D的组中显著改善。未发现显著 在JKOM评分、短表健康调查-36、肌力或躯体功能方面未观察到显著的组间差异。维生素E组的炎症标志物显著下降，但未观察到组间差异。除骨密度外，未发现其他显著的组间差异。 结论：作为下肢家庭锻炼的辅助手段，给予活性维生素D3或维生素E 24周并未对膝关节骨关节炎女性的症状、肌力或躯体功能产生显著的附加效应。单纯运动治疗仍然有效，维生素补充显示出营养素特异性趋势。
完整摘要 · 英文原文
BACKGROUND: Quadriceps weakness, inflammation, and reduced physical function are common in knee osteoarthritis (OA), and lower limb exercise therapy is an established non-pharmacological treatment. Vitamin D3 (vit D3) and vitamin E (vit E) have been proposed as adjunctive therapies; however, clinical findings are inconsistent. We aimed to examine whether combining lower limb home exercises with oral active vit D3 or vit E supplementation provides additive benefits compared with home exercise alone in women with symptomatic knee OA. METHODS: Eighty-eight postmenopausal women with knee OA (Kellgren-Lawrence grade 2-4; 71.9 ± 5.6 years) were randomly assigned to receive therapeutic lower limb home exercise only, home exercise with active vit D3 administration, or home exercise with vit E administration. Participants performed isometric lower limb exercises twice daily for 24 weeks. Subsequently, they were assessed using the Japanese knee osteoarthritis measure (JKOM) as the primary outcome. Secondary outcomes were short-form health survey, grip strength, quadriceps muscle strength, 10-m walk test, inflammatory markers, bone mineral density, and body composition. For data analyses, we used paired and independent t tests, analysis of variance, and analysis of covariance, adjusting for age, body mass index, and Kellgren-Lawrence grade. RESULTS: Eighty participants completed follow-up. All groups showed significant improvements in JKOM score, quadriceps muscle strength, and 10-m walk test. Grip strength improved significantly only in the group that received active vit D. No significant between-group differences were observed in JKOM scores, short-form health survey-36, muscle strength, or physical performance. Inflammatory markers decreased significantly in the vit E group, although between-group differences were not observed. No other significant between-group differences were found, except in bone mineral density. CONCLUSIONS: Administering active vit D3 or vit E for 24 weeks as an adjunct to lower limb home exercises did not yield significant additive effects on symptoms, muscle strength, or physical performance in women with knee OA. Exercise therapy alone remained effective, and vitamin supplementation showed nutrient-specific trends.
摘要 待译
BACKGROUND: Quadriceps weakness, inflammation, and reduced physical function are common in knee osteoarthritis (OA), and lower limb exercise therapy is an established non-pharmacological treatment. Vitamin D3 (vit D3) and vitamin E (vit E) have been proposed as adjunctive therapies; however, clinical findings are inconsistent. We aimed to examine whether combining lower limb home exercises with oral active vit D3 or vit E supplementation provides additive benefits compared with home exercise alone in women with symptomatic knee OA.…