Pharmacological and Non-Pharmacological approaches to manage Tension-Type Headache: a Systematic Review.
完整摘要 · 中文译文
引言：紧张型头痛（TTH），尤其是其慢性形式，构成一种持续性疼痛综合征，可显著损害躯体、认知、情感和社会功能。尽管这是最常见的头痛类型，但对于最佳长期治疗策略仍缺乏明确的共识。 目的：开展了一项系统评价，以评估药物和非药物治疗在被诊断为发作性或慢性TTH患者中的有效性证据，重点关注头痛疼痛及相关临床结局的改善。 方法：检索了五个电子数据库（PubMed、Scopus、Web of Science、Cochrane CENTRAL和PsycNET）以识别随机临床试验（RCT）。该评价在PROSPERO注册，遵循PRISMA指南，并使用Cochrane偏倚风险2工具。由于存在显著的临床和方法学异质性，按照无荟萃分析综合（SWiM）框架进行了叙述性综合，并使用GRADE方法评价证据确定性。 结果与结论：共纳入93项RCT，其中大多数具有中至低偏倚风险。基于本系统评价的发现，证据提示药物、手法和行为疗法各自具有特定的适应证。这些方法可根据每位患者的需求以个体化方式联合使用，目的是最大限度地实现长期症状缓解、尽量减少副作用，并最终改善生活质量 紧张型头痛（TTH）患者生活中的f。
完整摘要 · 英文原文
INTRODUCTION: Tension-Type Headaches (TTH), particularly in its chronic form, constitutes a persistent pain syndrome that can substantially impair physical, cognitive, emotional, and social functioning. Although this is the most common type of headache, there is a lack of clear consensus on the optimal long-term treatment strategy. OBJECTIVES: A systematic review was conducted to evaluate the evidence for the effectiveness of pharmacological and non-pharmacological treatments in patients diagnosed with episodic or chronic TTH, focusing on improvements in headache pain and related clinical outcomes. METHODS: A search across five electronic databases (PubMed, Scopus, Web of Science, Cochrane CENTRAL, and PsycNET) was conducted to identify randomized clinical trials (RCTs). The review was registered in PROSPERO, followed PRISMA guidelines and used the Cochrane Risk of bias 2 tool. Due to significant clinical and methodological heterogeneity, a narrative synthesis was performed following the Synthesis Without Meta-analysis (SWiM) framework, and the certainty of evidence was appraised using the GRADE approach. RESULTS AND CONCLUSIONS: Ninety-three RCTs were included, most of which had a moderate to low risk of bias. Based on the findings of this systematic review, the evidence suggests that pharmacological, manual, and behavioral therapies each have specific indications. These approaches can be combined in an individualized manner according to each patient's needs, with the aim of maximizing long-term symptom reduction, minimizing side effects, and ultimately improving quality of life in individuals with TTH.
摘要 待译
INTRODUCTION: Tension-Type Headaches (TTH), particularly in its chronic form, constitutes a persistent pain syndrome that can substantially impair physical, cognitive, emotional, and social functioning. Although this is the most common type of headache, there is a lack of clear consensus on the optimal long-term treatment strategy.…