Mindfulness-Based Intervention Improves Cognitive Function in Patients With Schizophrenia in Remitted: A Randomized Controlled Trial.
完整摘要 · 中文译文
背景：精神分裂症患者存在面部情绪识别（FER）、注意力、P300和生活质量（QoL）方面的缺陷，这些缺陷严重阻碍了功能康复。本研究旨在探讨正念干预（MBI）对这些结局的影响及潜在的中介机制。 方法：在这项为期8周的随机、单盲、对照研究中，共70例缓解期精神分裂症患者被随机分配到MBI组或对照组。在基线和第8周测量五因素正念量表（FFMQ）、FER、P300指标、持续操作测验-相同配对（CPT-IP）和精神分裂症生活质量量表（SQLS），以评估正念水平、认知功能、神经生理参数和QoL。采用线性混合模型评估干预效果。中介分析使用前后变化评分并结合bootstrap重抽样。 结果：对于主要结局，MBI显著改善了FFMQ（β = 16.750，95% CI [7.769, 25.731]，p < 0.001）。对于探索性结局，观察到P300潜伏期（β = -63.602，95% CI [-88.651, -38.554]，p < 0.001）和CPT-IP（β = 8.219，95% CI [4.004, 12.433]，p < 0.001）的显著改善。FER和P300波幅仅显示名义上的改善，SQLS显示出非显著趋势。观察到通过FER变化对SQLS变化存在显著间接效应（间接效应 = -6.343，95% CI [-11.467, -2.288]），但CPT-IP变化并未中介P300波幅的改善。 结论：MBI显著改善了正念的主要结局（FFMQ ）并在处理速度（P300潜伏期）和持续注意（CPT-IP）方面显示出有前景的探索性改善。FER变化可能代表与SQLS变化相关的潜在间接通路。这些发现支持MBI作为一种有前景的认知康复干预措施。 试验注册：https://www.chictr.org.cn，注册号ChiCTR 2500106735，注册日期：29/07/2025。
完整摘要 · 英文原文
BACKGROUND: Patients with schizophrenia exhibit deficits in facial emotion recognition (FER), attention, P300, and quality of life (QoL), which severely hinder functional recovery. This study aims to explore the effects of mindfulness-based intervention (MBI) on these outcomes and the potential mediating mechanisms. METHODS: In this 8-week randomized, single-blind, controlled study, a total of 70 remitted patients with schizophrenia were randomly assigned to the MBI group or the control group. The Five-Factor Mindfulness Scale (FFMQ), FER, P300 indices, Continuous Performance Test-Identical Pairs (CPT-IP), and Schizophrenia Quality of Life Scale (SQLS) were measured at baseline and week 8 to assess mindfulness levels, cognitive function, neurophysiological parameters, and QoL. Linear mixed models evaluated intervention effects. Mediation analyses used pre-post change scores with bootstrap resampling. RESULTS: For the primary outcome, MBI significantly improved FFMQ (β = 16.750, 95% CI [7.769, 25.731], p < 0.001). For the exploratory outcomes, significant improvements were observed for P300 latency (β = -63.602, 95% CI [-88.651, -38.554], p < 0.001) and CPT-IP (β = 8.219, 95% CI [4.004, 12.433], p < 0.001). FER and P300 amplitude showed nominal improvements only, and SQLS showed a non-significant trend. A significant indirect effect through FER change was observed for change in SQLS (indirect effect = -6.343, 95% CI [-11.467, -2.288]), but CPT-IP change did not mediate P300 amplitude improvement. CONCLUSION: MBI significantly improved the primary outcome of mindfulness (FFMQ) and showed promising exploratory improvements in processing speed (P300 latency) and sustained attention (CPT-IP). FER change may represent a potential indirect pathway associated with change in SQLS. These findings support MBI as a promising cognitive rehabilitation intervention. TRIAL REGISTRATION: https://www.chictr.org.cn, identifier ChiCTR 2500106735, registered on: 29/07/2025.
摘要 待译
BACKGROUND: Patients with schizophrenia exhibit deficits in facial emotion recognition (FER), attention, P300, and quality of life (QoL), which severely hinder functional recovery. This study aims to explore the effects of mindfulness-based intervention (MBI) on these outcomes and the potential mediating mechanisms. METHODS: In this 8-week randomized, single-blind, controlled study, a total of 70 remitted patients with schizophrenia were randomly assigned to the MBI group or the control group.…