Effects of Multicomponent Training on Body Composition and Cardiorespiratory Fitness in Adults With Type 2 Diabetes: A Randomized Controlled Trial.
完整摘要 · 中文译文
我们研究了为期14周、以小场地足球形式实施的多成分训练是否能改善2型糖尿病成人的身体成分、心肺适能和代谢结局。年龄40-70岁的成人（n = 111）被随机分配至运动组（n = 66；每周三次60分钟训练）或常规照护组（n = 45）。约束线性混合模型估计了变化值的组间差异。主要结局去脂体重（0.04 kg，95% CI -0.97至1.05）未检测到组间差异，脂肪量、体脂百分比或HbA1c亦无组间差异。与常规照护相比，运动使相对VO2peak（组间差异：2.80 mL·kg-1·min-1，95% CI 1.69至3.92）、绝对VO2peak（237 mL/min，95% CI 143至331）以及Yo-Yo间歇耐力1级测试表现（122 m，95% CI 12至232）产生更大增加。探索性分析显示，相对于常规照护，运动组的C肽（-10.3%，95% CI -19.0至-0.6）和HOMA2-IR（-10.8%，95% CI -20.1至-0.6）更低，HOMA2-%S更高（+12.2%，95% CI 0.6至25.1）。探索性三因素交互作用检验未提供明确证据表明胰高血糖素样肽-1受体激动剂（GLP-1RA）使用改变了对去脂体重、脂肪量或绝对VO2peak的影响。小场地足球改善了心肺适能，但未证实对去脂体重有益处。代谢方面的发现需要确认。试验注册：ClinicalTrials.gov标识符：NCT06478173。
完整摘要 · 英文原文
We investigated whether 14 weeks of multicomponent training delivered as small-sided soccer improves body composition, cardiorespiratory fitness, and metabolic outcomes in adults with type 2 diabetes. Adults aged 40-70 years (n = 111) were randomized to exercise (n = 66; three 60-min sessions per week) or usual care (n = 45). Constrained linear mixed models estimated between-group differences in change. No between-group difference was detected in the primary outcome, lean body mass (0.04 kg, 95% CI -0.97 to 1.05), or in fat mass, body fat percentage, or HbA1c. Compared with usual care, exercise produced greater increases in relative VO2peak (between-group difference: 2.80 mL·kg-1·min-1, 95% CI 1.69 to 3.92), absolute VO2peak (237 mL/min, 95% CI 143 to 331), and Yo-Yo Intermittent Endurance Level 1 test performance (122 m, 95% CI 12 to 232). Exploratory analyses showed lower C-peptide (-10.3%, 95% CI -19.0 to -0.6) and HOMA2-IR (-10.8%, 95% CI -20.1 to -0.6), and higher HOMA2-%S (+12.2%, 95% CI 0.6 to 25.1), in the exercise group relative to usual care. Exploratory three-way interaction tests provided no clear evidence that glucagon-like peptide-1 receptor agonist (GLP-1RA) use modified the effects on lean body mass, fat mass, or absolute VO2peak. Small-sided soccer improved cardiorespiratory fitness, whereas a benefit for lean body mass was not demonstrated. The metabolic findings require confirmation. Trial Registration: ClinicalTrials.gov identifier: NCT06478173.
摘要 待译
We investigated whether 14 weeks of multicomponent training delivered as small-sided soccer improves body composition, cardiorespiratory fitness, and metabolic outcomes in adults with type 2 diabetes. Adults aged 40-70 years (n = 111) were randomized to exercise (n = 66; three 60-min sessions per week) or usual care (n = 45). Constrained linear mixed models estimated between-group differences in change. No between-group difference was detected in the primary outcome, lean body mass (0.04 kg, 95% CI -0.97 to 1.05), or in fat mass, body fat percentage, or HbA1c.…