姜黄素在卵巢癌中的作用：机制见解与转化潜力。
完整摘要 · 中文译文
卵巢癌仍然是最致命的妇科恶性肿瘤，主要原因是诊断延迟、疾病进展迅速以及对标准化疗耐药。姜黄素是从姜黄中提取的天然多酚，已因其通过调节多种分子通路而具有潜在的抗癌特性而受到研究。本系统综述旨在探讨姜黄素及其纳米制剂在卵巢癌临床前模型中的机制性和治疗性作用。对21项研究的评估表明，姜黄素可能影响关键的信号通路，如磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）、核因子κβ（NF-κβ）、Janus激酶（JAK）/信号转导与转录激活因子3（STAT3）以及Wnt/β-连环蛋白。初步证据还提示，姜黄素可能通过改变肿瘤相关巨噬细胞极化来调节肿瘤微环境，尽管目前支持该发现的证据有限。这些相互作用与凋亡增加、增殖减少、上皮间质转化（EMT）抑制以及对顺铂和紫杉醇等化疗药物敏感性增强相关。纳米制剂——如胶束、树枝状体、脂质体和核壳纳米颗粒——已被证明与游离形式相比可提高姜黄素的生物利用度和治疗性能。虽然这些临床前研究结果提示了潜在获益，但仍需进一步的临床研究来证实姜黄素在卵巢癌支持治疗中的作用。 癌症。
完整摘要 · 英文原文
Ovarian cancer remains the most fatal gynecological malignancy, primarily due to delayed diagnosis, rapid progression, and resistance to standard chemotherapy. Curcumin, a natural polyphenol from Curcuma longa, has been investigated for its potential anticancer properties through the modulation of multiple molecular pathways. This systematic review examines the mechanistic and therapeutic roles of curcumin and its nanoformulations in preclinical models of ovarian cancer. Evaluation of 21 studies indicates that curcumin may influence key signaling pathways such as phosphoinositide 3-kinase (PI3K)/ protein kinase B (Akt)/ mechanistic target of rapamycin (mTOR), nuclear factor kappa β (NF-κβ), Janus kinase (JAK) /signal transducer and activator of transcription 3 (STAT3), and Wnt/β-catenin. Preliminary evidence also suggests that curcumin may modulate the tumor microenvironment through changes in tumor-associated macrophage polarization, although this finding is currently supported by limited evidence. These interactions are associated with increased apoptosis, reduced proliferation, inhibition of epithelial-to-mesenchymal transition (EMT), and enhanced sensitivity to chemotherapeutic agents like cisplatin and paclitaxel. Nanoformulations-such as micelles, dendrosomes, liposomes, and core-shell nanoparticles-have been shown to improve curcumin's bioavailability and therapeutic performance compared to its free form. While these preclinical findings suggest potential benefits, further clinical studies are necessary to confirm curcumin's role as a supportive treatment in ovarian cancer.