抑郁症药物
正文 · 中文译文
抗抑郁药 来自美国食品药品监督管理局（FDA）妇女健康办公室 妇女健康主题 老龄化 焦虑 节育 乳腺密度 照护 降胆固醇药物 临床试验 隐形眼镜护理 化妆品 抑郁症 糖尿病 膳食补充剂 食品安全 心脏健康 高血压 HIV HPV 狼疮 乳房X线摄影 用药安全 药物与妊娠 绝经 骨质疏松症 止痛药 多囊卵巢综合征（PCOS） 妊娠 睡眠问题 吸烟 纹身与永久性化妆 子宫肌瘤 更多妇女健康主题 妊娠暴露登记 临床哺乳研究 妇女免费出版物 打印与分享（PDF 1645KB） 了解抑郁症及其治疗选择 您感到抑郁吗？不要感到羞耻或孤单。女性比男性更容易感到抑郁，尽管这对两性来说都是一个重大问题。 有希望。 抑郁症可以通过药物或心理咨询来治疗。有时两者兼用。请与您的医疗保健提供者交谈，了解什么对您最有效。 使用以下信息帮助您与医疗保健提供者讨论称为抗抑郁药的药物，这些药物可以帮助治疗抑郁症。药物图表列出了可用于治疗该病症的FDA批准产品。您还会找到一些通用信息，帮助您明智地使用药物。请您的医疗保健提供者告诉您服用此类药物的风险。所提供的信息仅涵盖部分风险。此外，重要的是告诉您的医疗保健提供者您正在服用的任何药物。 抑郁的迹象 每个人有时都会感到悲伤。抑郁症患者大多数日子都会感到悲伤。这些感受会妨碍日常生活。 如果你感到抑郁，你可能会： 感到悲伤 一直感到疲倦 睡眠过少或总是睡觉 经常哭泣 对进食失去兴趣 进食过多 难以集中注意力 感到紧张或烦躁 想到死亡或试图自杀 注意到过去让你快乐的事情不再让你快乐 如果你发现这些迹象持续至少2周，请与你的医疗保健提供者谈谈你的感受；如果你有任何危险的想法或行为，请立即就医。 抑郁症的药物 有不同的抑郁症药物。 选择性5-羟色胺再摄取抑制剂（SSRI） 5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRI） 三环类和四环类抗抑郁药 非典型抗抑郁药 单胺氧化酶抑制剂（MAOI） N-甲基D-天冬氨酸（NMDA）拮抗剂 神经活性类固醇γ-氨基丁酸（GABA）-A受体正向调节剂 阅读以下信息，了解关于不同类型抑郁症药物的一些一般事实。 像所有药物一样，抑郁症药物可能会引起副作用。在未先与你的医疗保健提供者交谈的情况下，不要停止服药。告诉你的医疗保健提供者你遇到的任何问题，包括自杀念头。你的医疗保健提供者将帮助你找到最适合你的药物。 告诉您的医疗保健提供者您正在服用的任何药物。不要忘记感冒药、补充剂和草药（如圣约翰草）。其中一些可能与抗抑郁药相互作用并引起不必要的副作用。 订购或下载我们的免费药物记录本。 要向您的医疗保健提供者提出的问题 我正在服用什么药物？ 潜在的副作用是什么？ 在服用抑郁症药物期间，我应该避免使用哪些其他处方药？ 我应该避免哪些食物、草药（如圣约翰草）或非处方药？ 每种药物我应该什么时候服用？ 每种药物我每天服用几次？ 如果我怀孕或哺乳，我可以服用我的药物吗？ 选择性5-羟色胺再摄取抑制剂（SSRIs） 通用名商品名 Celexa西酞普兰 Lexapro艾司西酞普兰 Paxil、Paxil CR、Pexeva帕罗西汀 Prozac、Prozac Weekly氟西汀 Trintellix沃替西汀 Viibryd维拉佐酮 Zoloft舍曲林 警告 请勿与以下药物同服：单胺氧化酶抑制剂（MAOIs），以及在某些情况下硫利达嗪或Orap（匹莫齐特）。 如果您已注意到这些迹象至少2周，请与您的医疗保健提供者谈论您的感受；如果您有任何危险的想法或行为，请立即联系。 如果您患有窄角型青光眼，请谨慎使用。 常见副作用 恶心 震颤（发抖） 紧张不安 睡眠问题 性问题 出汗 激越 感到疲倦 不常见但严重的副作用 癫痫发作 异常出血或瘀伤 撤药症状 向您的医疗保健提供者咨询5-羟色胺综合征。 关于每种药物的风险和副作用的最新信息，请查阅Drugs@FDA 5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRIs） 商品名 通用名 Cymbalta 度洛西汀 Effexor、Effexor XR 文拉法辛 Fetzima 左米那普仑 Pristiq、Khedezla 去甲文拉法辛 警告 请勿与MAOIs（单胺氧化酶抑制剂）合用。 如有肝脏或肾脏问题，请慎用。 如患有窄角型青光眼，请慎用。 常见副作用 恶心 呕吐 口干 便秘 疲乏 嗜睡 头晕 出汗 性功能问题 较少见但严重的副作用 血压升高 异常出血或瘀伤 癫痫发作 请向您的医疗保健提供者咨询5-羟色胺综合征。 关于每种药物的风险和副作用的最新信息，请查阅Drugs@FDA 三环类和四环类抗抑郁药 商品名 通用名 Asendin 阿莫沙平 Elavil 阿米替林 Ludiomil 马普替林* Norpramin 地昔帕明 Pamelor 去甲替林 Sinequan 多塞平 Surmontil 曲米帕明 Tofranil 丙米嗪 Vivactil 普罗替林 *此为四环类药物。所列其他药物为三环类药物。 警告 请勿与MAOIs合用。 如患有窄角型青光眼，请慎用。 常见副作用 口干 便秘 视力模糊 嗜睡 低血压 较少见但严重的副作用 排尿困难 意识混乱 晕厥 癫痫发作 危及生命的心律失常 关于每种药物的风险和副作用的最新信息，请查阅Drugs@FDA 非典型抗抑郁药 商品名 通用名 Desyrel 曲唑酮 Serzone 奈法唑酮 警告 请勿与单胺氧化酶抑制剂（MAOI）同服；就奈法唑酮而言，若您正在服用三唑仑、阿普唑仑、匹莫齐特或卡马西平，请勿服用。 已有服用奈法唑酮的患者发生危及生命的肝衰竭的病例报告。应告知患者警惕肝功能障碍的体征和症状（黄疸、厌食、胃肠道不适、乏力等），一旦出现应立即告知其医疗保健提供者。 服用本药期间饮酒或服用巴比妥类药物时应谨慎。 常见副作用 口干 头晕 视力模糊 嗜睡或困倦 便秘 较少见但严重的副作用 持续时间长的疼痛性勃起 低血压 晕厥 意识混乱 肝衰竭 关于每种药物的风险和副作用的最新信息，请查阅 Drugs@FDA 非典型抗抑郁药 商品名 通用名 Remeron 米氮平 警告 请勿与 MAOI 同服。 若有心脏病或心律不齐的个人史或家族史，应谨慎使用。 常见副作用 嗜睡或困倦 体重增加 头晕 较少见但严重的副作用 粒细胞缺乏症（白细胞计数下降） 胆固醇升高 肝酶升高 请向您的医疗保健提供者咨询血清素综合征。 关于每种药物的风险和副作用的最新信息，请查阅 Drugs@FDA 非典型抗抑郁药 商品名 通用名 Wellbutrin、Wellbutrin SR、Wellbutrin XL 安非他酮 警告 服用此药期间饮酒需谨慎。 服用左旋多巴时需谨慎。 有癫痫发作或服用可能增加癫痫发作风险的药物时需谨慎。 常见副作用 头晕 便秘 恶心 呕吐 视力模糊 较少见但严重的副作用 癫痫发作 血压变化 如需了解每种药物风险和副作用的最新信息，请查阅 Drugs@FDA 单胺氧化酶抑制剂（MAOIs） 商品名 通用名 Emsam（皮肤贴片） 司来吉兰 Marplan 异卡波肼 Nardil 苯乙肼 Parnate 反苯环丙胺 警告 如果同时服用其他抗抑郁药或中枢神经系统兴奋剂或抑制剂，请勿服用 MAOIs。 请勿食用某些食物，如奶酪、葡萄酒、经过陈化的蛋白质食物，或任何含有酪胺的食物。 请勿服用感冒药或减充血剂。 常见副作用 恶心 坐立不安 睡眠问题 头晕 嗜睡 较少见但严重的副作用 头痛 卒中 晕厥 心悸 血压变化 如需了解每种药物风险和副作用的最新信息，请查阅 Drugs@FDA N-甲基-D-天冬氨酸（NMDA）拮抗剂 商品名 通用名 Spravato（鼻腔喷雾剂） 艾司氯胺酮 重要信息 艾司氯胺酮必须与口服抗抑郁药一起使用。 艾司氯胺酮应仅用于已尝试其他抗抑郁药但无效的患者。 给药后，患者可能出现镇静（疲倦）和解离（注意力、判断力和思维困难）。 由于这些风险，艾司氯胺酮仅可通过一项名为Spravato REMS的限制性项目获得。 艾司氯胺酮是一种鼻喷雾剂，必须在经REMS项目认证的医疗机构中给药，医疗提供者可在每次给药后对患者进行两小时的镇静和解离监测。 警告 给药后存在暂时性镇静（疲倦）和解离（注意力、判断力和思维困难）的风险。 艾司氯胺酮是一种联邦管制物质，存在被误用和滥用的可能。 可能导致暂时性注意力、判断力、思维、反应速度和运动技能困难。 在次日经过充分睡眠之前，请勿驾驶或操作机械。 可能伤害未出生的婴儿。患者应与其医疗提供者讨论在妊娠期间服用此药的风险。 常见副作用 解离（注意力、判断力和思维困难） 头晕 恶心 嗜睡 旋转感 感觉减退或敏感度下降 焦虑 较不常见但严重的副作用 血压升高 如需了解每种药物风险和副作用的最新信息，请查阅Drugs@FDA 神经活性类固醇γ-氨基丁酸（GABA）-A受体正向调节剂 品牌名称通用名称 Zulresso（此药以静脉输注方式给药。）brexanolone 重要信息 Brexanolone 获批用于治疗成人产后抑郁症（PPD）。 Brexanolone 通过持续静脉（IV）输注给药，总时长 60 小时。 在接受 brexanolone 给药期间，患者可能出现过度疲劳或突然失去意识或意识状态改变。 鉴于这些风险，brexanolone 仅可通过名为 Zulresso REMS 的限制性项目获得。该药只能在经 Zulresso REMS 认证的医疗机构中给药。 在 brexanolone 给药期间必须对患者进行监测，并向医疗保健提供者报告任何过度疲劳的体征和症状。 在开始使用 brexanolone 之前，如果您可能怀孕，请告知您的医疗保健提供者。 警告 镇静（疲劳）和突然失去意识的风险。 Brexanolone 是联邦管制物质，存在被误用和滥用的可能。 将 brexanolone 与阿片类药物或某些其他称为中枢神经系统（CNS）抑制剂的药物合用可能增加疲劳或突然失去意识的风险。 自杀想法和行为的风险 Brexanolone 可被滥用或导致依赖。 常见副作用 镇静（疲劳） 口干 失去意识 潮红 较少见但严重的副作用 自杀想法和行为 抑郁与妊娠 一些女性在怀孕期间或分娩后出现抑郁。其他女性注意到其抑郁在妊娠期间加重。 没有人知道孕期或产后抑郁症的确切原因。它可能与以下因素有关： 压力和睡眠问题 激素——女性生完孩子后，激素水平会迅速下降 怀孕前就患有抑郁症 缺乏家人和朋友的支持 年轻——生孩子时越年轻，就越容易患抑郁症 女性应与医疗保健提供者讨论在孕期和产后服用抗抑郁药的风险。 抑郁症会使女性难以照顾自己和婴儿。与医疗保健提供者谈谈你的感受很重要。此外，尽量从家人、朋友或支持团体那里获得一些帮助。 请亲戚照看你的宝宝几个小时。 加入新手妈妈互助小组。 请朋友为你的家人做一顿饭或帮忙做家务。 “产后情绪低落” 生孩子可能是一段快乐的时光。然而，有些女性在生完孩子后会经常哭泣并感到悲伤。这被称为“产后情绪低落”。这些感觉通常在大约两周后消失。 如果两周后你仍然感到悲伤，请去看医疗保健提供者或去诊所。你可能患了抑郁症。这种类型的抑郁症被称为产后抑郁症，因为它始于女性生孩子之后。女性在生完孩子后长达一年内都可能患上这种抑郁症。 注册妊娠登记系统 妊娠暴露登记系统是收集孕期服用处方药或接种疫苗的女性信息的研究。 妊娠登记系统可以帮助女性及其医生更多地了解抑郁症药物如何影响女性在妊娠期间的情况。 美国食品药品监督管理局（FDA）不开展妊娠研究，但维护一份登记系统清单。请访问以下网址，查看是否有针对您的抑郁症药物或其他药物的登记系统：www.fda.gov/pregnancyregistries 抑郁症与您的孩子 与成人一样，儿童和青少年也可能感到抑郁。您应当留意孩子的抑郁迹象。如果您注意到孩子的行为发生变化，请与他们交谈。如果您仍有担忧，请与孩子的医疗保健提供者沟通。 氟西汀（Prozac）是唯一获FDA批准用于儿童抑郁症的药物。氟西汀（Prozac）和艾司西酞普兰（Lexapro）是仅有的获FDA批准用于青少年抑郁症的药物。请与您的医疗保健提供者讨论服用抑郁症药物的儿童和青少年的重要警告。 重要警告 一些服用抗抑郁药的儿童和青少年在开始治疗或改变剂量时，可能更容易产生伤害或杀死自己的想法。 如果出现以下情况，请致电医疗保健提供者或911： 试图伤害或杀死自己 谈论伤害或杀死自己的具体方式 谈论或试图伤害他人 如果此人出现以下任何迹象，请立即致电您的医疗保健提供者： 谈论死亡或自杀 行为开始出现很大变化 异常活跃 有严重的睡眠问题 变得暴力或异常愤怒 变得激越或无法静坐 抑郁症药物及信息截至2019年9月为最新。有关治疗抑郁症药物风险和副作用的最新信息，请参阅Drugs@FDA。 了解更多 美国国家精神卫生研究所（NIMH） 网站：www.nimh.nih.gov 电话：1-866-615-6464 TTY/TDD：1-866-415-8051 资源 抑郁症/美国卫生与公众服务部妇女健康办公室 妇女免费出版物 妇女健康主题 美国食品药品监督管理局妇女健康办公室 合作邀请 内容更新日期： 11/18/2019 受监管产品 药品 抗抑郁药 主题 消费者健康 健康主题 抑郁症
正文 · 英文原文
Depression Medicines From the FDA Office of Women's Health Women's Health Topics Aging Anxiety Birth control Breast density Caregiving Cholesterol medicines Clinical trials Contact lens care Cosmetics Depression Diabetes Dietary supplements Food safety Heart health High blood pressure HIV HPV Lupus Mammography Medication safety Medicine and pregnancy Menopause Osteoporosis Pain medicines PCOS Pregnancy Sleep problems Smoking Tattoos and permanent makeup Uterine fibroids More Women's Health Topics Pregnancy Exposure Registries Clinical Lactation Studies Free publications for women Print and Share (PDF 1645KB) Understanding Depression and Your Treatment Options Do you feel depressed? Do not feel ashamed or alone. Women are more likely than men to feel depressed, although it is a major problem for both sexes. There is hope. Depression can be treated with medicine or counseling. Sometimes both are used. Talk with your healthcare provider to find out what will work best for you. Use the following information to help you talk to your healthcare provider about medicines called antidepressants that can help treat depression. The medicine charts list FDA-approved products that are available to treat this condition. You will also find some general information to help you use your medicine wisely. Ask your healthcare provider to tell you about the risks of taking this type of medicine. The information provided only covers some of the risks. Also, it is important to tell your healthcare provider about any medicine that you are taking. Signs of Depression Everyone feels sad at times. People with depression feel sad most days. These feelings can get in the way of everyday life. If you are depressed, you may: Feel sad Feel tired all the time Sleep too little or all the time Cry a lot Lose interest in eating Eat too much Have trouble paying attention Feel nervous or cranky Think about death or trying to kill yourself Notice that things that used to make you happy do not make you happy anymore Talk with your healthcare provider about your feelings if you have noticed these signs for at least 2 weeks or immediately if you have any dangerous thoughts or behaviors. Medicines for Depression There are different kinds of medicine for depression. Selective Serotonin Reuptake Inhibitors (SSRI) Serotonin and Norepinephrine Reuptake Inhibitors (SNRI) Tricyclic and Tetracyclic Antidepressants Atypical Antidepressants Monoamine Oxidase Inhibitors (MAOIs) N-methyl D-aspartate (NMDA) Antagonist Neuroactive Steroid Gamma-Aminobutyric Acid (GABA)-A Receptor Positive Modulator Read the following information to find out some general facts about the different kinds of medicine for depression. Like all drugs, depression medicine may cause side effects. Do not stop taking your medicine without first talking to your healthcare provider. Tell your healthcare provider about any problems you are having, including thoughts about suicide. Your healthcare provider will help you find the medicine that is best for you. Tell your healthcare provider about any medicine that you are taking. Do not forget about cold medicines, supplements, and herbals like St. John’s Wort. Some of these can interact with antidepressants and cause unwanted side effects. Order or Download our Free Medicine Record Keeper. Questions To Ask Your Healthcare Provider What medicine am I taking? What are the potential side effects? What other prescription medicine should I avoid while taking medicine for depression? What foods, herbs (like St. John’s Wort), or over-the-counter medicine should I avoid? When should I take each medicine? How many times per day do I take each medicine? Can I take my medicine if I am pregnant or nursing? Selective Serotonin Reuptake Inhibitors (SSRIs) Generic NameBrand Name Celexacitalopram Lexaproescitalopram Paxil, Paxil CR, Pexevaparoxetine Prozac, Prozac Weeklyfluoxetine Trintellixvortioxetine Viibrydvilazodone Zoloftsertraline Warnings Do not take with these medicines: Monoamine Oxidase Inhibitors (MAOIs), and in some cases thioridazine or Orap (pimozide). Talk with your healthcare provider about your feelings if you have noticed these signs for at least 2 weeks or immediately if you have any dangerous thoughts or behaviors. Use with caution if you have narrow-angle glaucoma. Common Side Effects Nausea Tremor (shaking) Nervousness Problems sleeping Sexual problems Sweating Agitation Feeling tired Less Common, but Serious, Side Effects Seizures Abnormal bleeding or bruising Withdrawal symptoms Ask your healthcare provider about serotonin syndrome. For up-to-date information about the risks and side effects for each drug, check Drugs@FDA Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) Brand NameGeneric Name Cymbaltaduloxetine Effexor, Effexor XRvenlafaxine Fetzimalevomilnacipran Pristiq, Khedezladesvenlafaxine Warnings Do not take with MAOIs. Use with care if you have liver or kidney problems. Use with caution if you have narrow-angle glaucoma. Common Side Effects Nausea Vomiting Dry mouth Constipation Fatigue Feeling drowsy Dizziness Sweating Sexual problems Less Common, but Serious, Side Effects Increase in blood pressure Abnormal bleeding or bruising Seizures Ask your healthcare provider about serotonin syndrome. For up-to-date information about the risks and side effects for each drug, check Drugs@FDA Tricyclic and Tetracyclic Antidepressants Brand NameGeneric Name Asendinamoxapine Elavilamitriptyline Ludiomilmaprotiline* Norpramindesipramine Pamelornortriptyline Sinequandoxepin Surmontiltrimipramine Tofranilimipramine Vivactilprotriptyline *This is a tetracyclic. The others listed are tricyclic. Warnings Do not take with MAOIs. Use with caution if you have narrow-angle glaucoma. Common Side Effects Dry mouth Constipation Blurred vision Drowsiness Low blood pressure Less Common, but Serious, Side Effects Problems urinating Confusion Fainting Seizures Life-threatening irregular heartbeat For up-to-date information about the risks and side effects for each drug, check Drugs@FDA Atypical Antidepressants Brand NameGeneric Name Desyreltrazodone Serzonenefazodone Warnings Do not take with MAOIs, and, for nefazodone, if you are taking triazolam, alprazolam, pimozide, or carbamazepine. Cases of life-threatening liver failure have been reported in patients taking nefazodone. Patients should be advised to be alert for signs and symptoms of liver dysfunction (jaundice, anorexia, gastrointestinal complaints, malaise, etc.) and to report them to their healthcare provider immediately if they occur. Use caution if you drink alcohol or take barbiturates while taking this medicine. Common Side Effects Dry mouth Dizziness Blurred vision Feeling drowsy or sleepy Constipation Less Common, but Serious, Side Effects Painful erection that lasts a long time Low blood pressure Fainting Confusion Liver failure For up-to-date information about the risks and side effects for each drug, check Drugs@FDA Atypical Antidepressants Brand NameGeneric Name Remeronmirtazapine Warnings Do not take with MAOIs. Use caution if you have a personal history or family history of heart disease or irregular heart rhythm. Common Side Effects Feeling drowsy or sleepy Weight gain Dizziness Less Common, but Serious, Side Effects Agranulocytosis (drop in white blood cell count) Increase in cholesterol Increase in liver enzymes Ask your healthcare provider about Serotonin Syndrome. For up-to-date information about the risks and side effects for each drug, check Drugs@FDA Atypical Antidepressants Brand NameGeneric Name Wellbutrin, Wellbutrin SR, Wellbutrin XLbupropion Warnings Use caution if you drink alcohol while taking this medicine. Use caution if you take levodopa. Use caution if you have seizures or take medicines that raise your chance of having a seizure. Common Side Effects Dizziness Constipation Nausea Vomiting Blurred vision Less Common, but Serious, Side Effects Seizures Blood pressure changes For up-to-date information about the risks and side effects for each drug, check Drugs@FDA Monoamine Oxidase Inhibitors (MAOIs) Brand NameGeneric Name Emsam (Skin Patch)selegiline Marplanisocarboxzaid Nardilphenelzine Parnate tranylcypromine Warnings Do not take MAOIs if you are also taking other medicines for depression or central nervous system stimulants or depressants. Do not eat certain foods like cheese, wine, protein foods that have been aged, or any food containing tyramine. Do not take cold pills or decongestants. Common Side Effects Nausea Restlessness Problems sleeping Dizziness Drowsiness Less Common, but Serious, Side Effects Headache Stroke Fainting Heart palpitations Blood pressure changes For up-to-date information about the risks and side effects for each drug, check Drugs@FDA N-methyl D-aspartate (NMDA) Antagonist Brand NameGeneric Name Spravato (nasal spray)esketamine Important Information Esketamine must be taken with an oral antidepressant. Esketamine should be used only in patients who have tried other depression medicines that did not work for them. Patients may experience sedation (tiredness) and dissociation (difficulty with attention, judgment, and thinking) after administration. Because of these risks, esketamine is available only through a restricted program, called the Spravato REMS. Esketamine is a nasal spray that must be administered in a healthcare setting that is certified in the REMS program where the healthcare provider can monitor the patient for sedation and dissociation for two hours after each dose. Warnings Risk for temporary sedation (tiredness) and dissociation (difficulty with attention, judgment, and thinking) after administration. Esketamine is a federal controlled substance and has the potential to be misused and abused. May cause temporary difficulty with attention, judgment, thinking, reaction speed, and motor skills. Do not drive or operate machinery until the next day after a restful sleep. May harm an unborn baby. Patients should talk to their healthcare provider about the risks of taking this medicine during pregnancy. Common Side Effects Dissociation (difficulty with attention, judgment, and thinking)) Dizziness Nausea Sleepiness Spinning sensation Decreased feeling or sensitivity Anxiety Less Common, but Serious, Side Effects Increase in blood pressure For up-to-date information about the risks and side effects for each drug, check Drugs@FDA Neuroactive Steroid Gamma-Aminobutyric Acid (GABA)-A Receptor Positive Modulator Brand NameGeneric Name Zulresso (This medicine is given as an intravenous infusion.)brexanolone Important Information Brexanolone is approved for the treatment of postpartum depression (PPD) in adults. Brexanolone is given by continuous intravenous (IV) infusion over a total of 60 hours. Patients may experience excessive tiredness or sudden loss of consciousness or changes in their state of consciousness while brexanolone is being given. Because of these risks, brexanolone is available only through a restricted program called the Zulresso REMS. It can only be administered in a healthcare facility that is certified in the Zulresso REMS. Patients must be monitored while brexanolone is being given and report any signs and symptoms of excessive tiredness to a healthcare provider. Before starting brexanolone, tell your healthcare provider if you may be pregnant. Warnings Risk for sedation (tiredness) and sudden loss of consciousness. Brexanolone is a federal controlled substance and has the potential to be misused and abused. Taking brexanolone with opioids or certain other medicines called CNS depressants may increase the risks of tiredness or sudden loss of consciousness. Risk for suicidal thoughts and behaviors Brexanolone can be abused or lead to dependence. Common Side Effects Sedation (tiredness) Dry mouth Loss of consciousness Flushing Less Common, but Serious, Side Effects Suicidal thoughts and behaviors Depression and Pregnancy Some women become depressed when they are pregnant or after they give birth. Other women notice that their depression gets worse during pregnancy. No one knows the exact cause of depression during or after pregnancy. It may have something to do with: Stress and sleep problems Hormones - after a woman has a baby, her hormone levels drop quickly Having depression before you get pregnant Lack of support from family and friends Young age – the younger you are when you have your baby the more likely you are to become depressed Women should talk with their healthcare provider about the risks of taking antidepressants during pregnancy and after the baby’s birth. Depression can make it hard for a woman to take care of herself and her baby. It is important to talk to your healthcare provider about your feelings. Also, try to get some help from your family, friends, or a support group. Ask a relative to watch your baby for a few hours. Join a group for new mothers. Ask a friend to cook a meal for your family or to help with chores. “The Baby Blues” Having a baby can be a joyful time. However, some women cry a lot and feel sad right after they have a baby. This is called “the baby blues.” These feelings usually go away after about two weeks. If you still feel sad after two weeks, go to your healthcare provider or clinic. You may be depressed. This type of depression is called postpartum depression because it starts after a woman has a baby. A woman can have this kind of depression up to one year after she has a baby. Sign Up for a Pregnancy Registry Pregnancy Exposure Registries are research studies that collect information from women who take prescription medicines or vaccines during pregnancy. Pregnancy registries can help women and their doctors learn more about how depression medicines affect women during pregnancy. The FDA does not run pregnancy studies, but it keeps a list of registries. Check to see if there is a registry for your depression medicine or other medicines at: www.fda.gov/pregnancyregistries Depression and Your Children Like adults, children and teens can also feel depressed. You should watch your children for signs of depression. Talk with your children if you notice changes in their behavior. Talk with your child’s healthcare provider if you are still concerned. Prozac (fluoxetine) is the only medicine that is approved by FDA for use in children with depression. Prozac (fluoxetine) and Lexapro (escitalopram) are the only FDA-approved medicines for teens with depression. Talk with your healthcare provider about important warnings for children and teens who take medicine for depression. Important Warnings Some children and teens who take antidepressants may be more likely to think about hurting or killing themselves when starting treatment or when dose is changed. Call a healthcare provider or 911 if the person: Tries to hurt or kill himself/herself Talks about specific ways they plan to hurt or kill himself/herself Talks about or tries to harm others Call your healthcare provider right away if the person shows any of these signs: Talks about dying or suicide Starts acting very differently Is abnormally active Has severe problems sleeping Becomes violent or abnormally angry Becomes agitated or can't sit still Depression medicines and information is current as of September 2019. For the most up-to-date information about the risks and side effects of medicines for treatment of Depression, please see Drugs@FDA. To Learn More National Institute of Mental Health (NIMH) Web: www.nimh.nih.gov Phone: 1-866-615-6464 TTY/TDD: 1-866-415-8051 Resources Depression/HHS Office of Women's Health Free Publications For Women Women's Health Topics FDA Office of Women's Health An Invitation to Collaborate Content current as of: 11/18/2019 Regulated Product(s) Drugs Antidepressants Topic(s) Consumer Health Health Topic(s) Depression