科研动态期刊摘要
跨越人生八个十年的肿瘤转录组图谱揭示早发性结直肠癌的独特特征
Nature Medicine · 2026-11-05
摘要
《自然·医学》，在线发表：2026年11月4日；doi:10.1038/s41591-026-04771-2 早发性结直肠癌的发病率正在上升，但其在生物学上是否与平均发病年龄的疾病不同尚不清楚。对跨越年龄连续谱的结直肠肿瘤转录组进行图谱绘制显示，年轻成人的肿瘤含有更多基质细胞，且长非编码RNA及与上皮-间质转化相关基因的表达增加。
English
A tumor transcriptomic atlas across eight decades of life reveals distinct features of early-onset colorectal cancer
Nature Medicine, Published online: 04 November 2026; doi:10.1038/s41591-026-04771-2 The incidence of early-onset colorectal cancer is rising, but whether it is biologically distinct from average-onset disease is unclear. Mapping of the transcriptome of colorectal tumors across the age continuum shows that tumors in younger adults contain more stromal cells and have increased expression of long non-coding RNAs and genes associated with epithelial-to-mesenchymal transition.