科研动态期刊摘要
急性缺血性卒中的静脉溶栓——新方向
NEJM · 2026-11-05
完整摘要 · 中文译文
在过去5年中，急性缺血性卒中患者静脉溶栓（IVT）的应用已发生实质性变化。将IVT与血管内取栓相结合——后者可改善大血管闭塞所致卒中患者的结局——一直是一项特殊挑战。本综述讨论了IVT与取栓术所针对的潜在血管靶点、替奈普酶日益取代阿替普酶的使用、IVT适应证的不断扩大，以及可能提高IVT成功率的辅助药物和给药方法。
完整摘要 · 英文原文
In the past 5 years, substantial changes have been made in the use of intravenous thrombolysis (IVT) in patients with acute ischemic stroke. Integrating IVT with endovascular thrombectomy, which improves outcomes in patients with stroke due to large cerebral vessel occlusion, has been a particular challenge. This review discusses the underlying vascular targets for IVT and thrombectomy, the increasing use of tenecteplase instead of alteplase, broadening indications for the use of IVT, and ancillary drugs and dosing methods that may augment the success of IVT.
English
Intravenous Thrombolysis for Acute Ischemic Stroke — New Directions