慢加急性肝衰竭：关于定义的全球多学会共识。
完整摘要 · 中文译文
慢加急性肝衰竭（ACLF）多学会协调倡议是一项全球协作努力，旨在为ACLF的定义、诊断、分级和管理建立统一、循证的框架。该共识基于现有区域定义的优点并整合多样的国际视角，为临床实践、研究和教育提供了务实、全球适用的基础。它还建立了用于患者分层、器官功能障碍和衰竭评估、重症监护管理、肝移植以及未来II/III期试验设计的共同框架。标准化、与监管要求一致的终点有望提高跨研究可比性、加强协作，并加速有效ACLF疗法的开发。
完整摘要 · 英文原文
The acute-on-chronic liver failure (ACLF) multisociety harmonisation initiative represents a global collaborative effort to establish a unified, evidence-based framework for the definition, diagnosis, grading, and management of ACLF. Building on the strengths of existing regional definitions and integrating diverse international perspectives, this consensus provides a pragmatic, globally applicable foundation for clinical practice, research, and education. It also establishes a common framework for patient stratification, organ dysfunction and failure assessment, critical care management, liver transplantation, and the design of future phase II/III trials. Standardised, regulatory-aligned endpoints are expected to improve cross-study comparability, strengthen collaboration, and accelerate development of effective ACLF therapies.