[评论]《柳叶刀》脓毒症委员会：转变脓毒症诊疗与结局
摘要
脓毒症是一种危及生命的器官功能障碍，由宿主对感染的反应失调引起1，常见且常常致命。2,3 目前对急性不适的脓毒症患者的诊疗标准依赖于临床医生的早期怀疑、感染源控制（如脓肿引流和清创）、给予经验性广谱抗菌药物，以及对衰竭的重要器官提供生命支持。4 尽管此类维持生命的治疗通常在重症监护病房中实施，但全球大多数脓毒症患者是在重症监护病房之外或无此类设施的病房中接受治疗的。
English
Sepsis, a life-threatening organ dysfunction, is caused by dysregulated host responses to infection1 and is common, and often deadly.2,3 The current standard of care for the acutely unwell patient with sepsis relies on early suspicion by the clinician, infection source control (eg, abscess drainage and debridement), administering empirical broad spectrum antimicrobials, and life support for failing vital organs.4 Although such life-sustaining therapies are commonly delivered in intensive care units, globally most patients with sepsis are managed outside intensive care units or in wards without such facilities.