🎯 Therapeutic Drug Monitoring (TDM) Targets
UseLook up the target range and when to sample (trough/peak/steady state). Interpret levels with clinical effica…
SourceTherapeutic drug monitoring guidance and product labelling
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
Paste the link in Slack, Teams, X, or LinkedIn — the preview image comes from this page’s Open Graph card.
Methodology · worked example, guidelines & full notes
Units and assays vary between laboratories.
When to use
Look up the target range and when to sample (trough/peak/steady state). Interpret levels with clinical efficacy and toxicity.
How it works
Examples: digoxin 0.5–2.0 ng/mL (HF 0.5–0.9); phenytoin total 10–20 µg/mL; lithium 0.6–1.0 mmol/L; vancomycin AUC/MIC 400–600.
Key points
- Units and assays vary between laboratories.
- Wrong sampling timing (before steady state, not a true trough/peak) causes misinterpretation.
- A subtherapeutic level with good clinical response need not be changed.
- For vancomycin and aminoglycosides see the dedicated dosing tools.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Drug | Lithium |
|---|
→Target rangeMaintenance 0.6–1.0, acute 0.8–1.2 mmol/L
- Sampling：12 h after last dose (before the morning dose)
- Toxicity：> 1.5 toxic; dehydration/NSAID/diuretic/ACEI raise it
| Drug | Digoxin |
|---|
→Target range0.5–2.0 ng/mL (HF 0.5–0.9)
- Sampling：≥ 6–8 h after last dose
- Toxicity：> 2.0 toxic; hypokalaemia/hypomagnesaemia/renal impairment sensitise
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using Therapeutic Drug Monitoring (TDM) Targets?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does Therapeutic Drug Monitoring (TDM) Targets upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Therapeutic Drug Monitoring (TDM) Targets calculated in practice? Can you show a worked example?
- Inputs: Drug Lithium → Result: Target range Maintenance 0.6–1.0, acute 0.8–1.2 mmol/L（Sampling: 12 h after last dose (before the morning dose), Toxicity: > 1.5 toxic; dehydration/NSAID/diuretic/ACEI raise it） Inputs: Drug Digoxin → Result: Target range 0.5–2.0 ng/mL (HF 0.5–0.9)（Sampling: ≥ 6–8 h after last dose, Toxicity: > 2.0 toxic; hypokalaemia/hypomagnesaemia/renal impairment sensitise）