💊 Acetaminophen (Paracetamol) Dose & Toxicity Threshold
UseVerify therapeutic dosing and triage an acute overdose by mg/kg ingested. Use the Rumack-Matthew nomogram on …
SourceRumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics 1975; product labelling
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Lower the ceiling with chronic alcohol use, liver disease, malnutrition/fasting or isoniazid.
When to use
Verify therapeutic dosing and triage an acute overdose by mg/kg ingested. Use the Rumack-Matthew nomogram on a timed 4-hour level for the definitive NAC decision.
How it works
Adult (≥ 50 kg): single ≤ 1 g, daily ≤ 4 g. Child (< 50 kg): ≤ 15 mg/kg/dose, ≤ 75 mg/kg/day. Acute toxic threshold ≥ 150 mg/kg.
Key points
- Lower the ceiling with chronic alcohol use, liver disease, malnutrition/fasting or isoniazid.
- Single acute ingestion ≥ 150 mg/kg (adult ≈ 7.5–10 g) risks hepatotoxicity.
- NAC within 8 hours is nearly fully hepatoprotective.
- Watch for hidden acetaminophen in combination products and for extended-release kinetics.
References
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using Acetaminophen (Paracetamol) Dose & Toxicity Threshold?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does Acetaminophen (Paracetamol) Dose & Toxicity Threshold upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.