🎗️ Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)
UseDecide adjuvant pelvic radiation for the intermediate-risk group after radical hysterectomy for early cervica…
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SourceSedlis A, et al. A randomized trial of pelvic radiation therapy versus no further therapy... (GOG-9…
Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
Scene next step
📋gyn oncoOpen scene pack →Related scores
Matching pathway
🧭cervical_ca_mriOpen pathway →Score + version; reference only — not a substitute for care · no HIS write
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Methodology · worked example, guidelines & full notes
Clinical takeaway
The Sedlis criteria apply only when nodes, margins and parametria are negative; positive findings are high-risk (Peters) and get chemoradiation.
When to use
Decide adjuvant pelvic radiation for the intermediate-risk group after radical hysterectomy for early cervical cancer.
How it works
Meets if any: LVSI+ & deep 1/3 (any size); LVSI+ & mid 1/3 & ≥ 2 cm; LVSI+ & superficial 1/3 & ≥ 5 cm; LVSI− & mid/deep 1/3 & ≥ 4 cm.
Key points
- The Sedlis criteria apply only when nodes, margins and parametria are negative; positive findings are high-risk (Peters) and get chemoradiation.
- Meeting the criteria supports adjuvant pelvic external-beam radiation — GOG-92 showed roughly a 46% reduction in recurrence.
- Whether to add concurrent platinum chemotherapy for intermediate risk is individualised and varies by centre.
- NCCN notes risk factors are not strictly limited to the original Sedlis combinations.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Lymphovascular space invasion (LVSI) | Positive |
|---|---|
| Cervical stromal invasion depth | Middle 1/3 |
| Maximum tumour diameter | 3.0 cm |
→Sedlis criteriaMet (adjuvant RT advised)
- Verdict：Meets Sedlis intermediate-risk criteria: LVSI-positive + middle 1/3 invasion + ≥ 2 cm
- Management direction：Adjuvant pelvic external-beam radiation is advised (GOG-92 showed ~ 46% recurrence reduction); whether to add concurrent platinum chemotherapy is individualised (some centres add chemo even for intermediate risk)
- Applicability：Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation
| Lymphovascular space invasion (LVSI) | Negative |
|---|---|
| Cervical stromal invasion depth | Superficial 1/3 |
| Maximum tumour diameter | 3.0 cm |
→Sedlis criteriaNot met
- Verdict：Does not meet any Sedlis combination (LVSI/depth/size below threshold)
- Management direction：Intermediate risk not reached: generally observation/follow-up; if high-risk factors are present (positive parametria/nodes/margins, Peters criteria) treat as high-risk with concurrent chemoradiation
- Applicability：Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery) calculated in practice? Can you show a worked example?
- Inputs: Lymphovascular space invasion (LVSI) Positive, Cervical stromal invasion depth Middle 1/3, Maximum tumour diameter 3.0 cm → Result: Sedlis criteria Met (adjuvant RT advised)（Verdict: Meets Sedlis intermediate-risk criteria: LVSI-positive + middle 1/3 invasion + ≥ 2 cm, Management direction: Adjuvant pelvic external-beam radiation is advised (GOG-92 showed ~ 46% recurrence reduction); whether to add concurrent platinum chemotherapy is individualised (some centres add chemo even for intermediate risk), Applicability: Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation） Inputs: Lymphovascular space invasion (LVSI) Negative, Cervical stromal invasion depth Superficial 1/3, Maximum tumour diameter 3.0 cm → Result: Sedlis criteria Not met（Verdict: Does not meet any Sedlis combination (LVSI/depth/size below threshold), Management direction: Intermediate risk not reached: generally observation/follow-up; if high-risk factors are present (positive parametria/nodes/margins, Peters criteria) treat as high-risk with concurrent chemoradiation, Applicability: Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation）