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🫘 Renal Dose Adjustment Quick Reference

UseBedside reminder of renal thresholds and adjustments for 13 commonly used drugs. Not exhaustive — confirm aga…

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SourceKDIGO and FDA product labelling for renally-cleared drugs

Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders

This-shift next steps

After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.

Scene next step
📋Renal function / dosingOpen scene pack →
Related scores
Matching pathway
🧭hyperkOpen pathway →
Score + version; reference only — not a substitute for care · no HIS write

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Methodology · worked example, guidelines & full notes
Clinical takeaway

Thresholds change with label updates — always verify the current label.

When to use

Bedside reminder of renal thresholds and adjustments for 13 commonly used drugs. Not exhaustive — confirm against the latest label.

How it works

Per-drug bands by CrCl/eGFR (e.g. metformin contraindicated < 30; apixaban 2.5 mg BID if ≥ 2 of age ≥ 80 / weight ≤ 60 kg / SCr ≥ 1.5).

Key points

  • Thresholds change with label updates — always verify the current label.
  • Match the renal-function method (Cockcroft-Gault vs CKD-EPI) to the drug's PK studies.
  • NSAIDs: avoid below eGFR 30 and beware the ACEI/ARB + diuretic 'triple whammy'.
  • Individualise to the whole patient and institutional protocol.

References

Worked calculation

The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.

DrugGabapentin

→Renal key pointReduce by CrCl band

  • CrCl ≥ 60：Usual
  • CrCl 30–59：Reduce
  • CrCl 15–29：Reduce further
DrugMetformin

→Renal key pointeGFR < 30 contraindicated

  • eGFR ≥ 45：Usual dose
  • eGFR 30–45：Do not start new; if already on, weigh risk/benefit and consider reducing (e.g. 500 mg qd)
  • eGFR < 30：Contraindicated (lactic acidosis risk)
Verification & sources · governance
FAQ

Frequently asked questions

What are the limits and cautions when using Renal Dose Adjustment Quick Reference?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
Does Renal Dose Adjustment Quick Reference upload patient data? Where is it calculated?
Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
How is Renal Dose Adjustment Quick Reference calculated in practice? Can you show a worked example?
Inputs: Drug Gabapentin → Result: Renal key point Reduce by CrCl band（CrCl ≥ 60: Usual, CrCl 30–59: Reduce, CrCl 15–29: Reduce further） Inputs: Drug Metformin → Result: Renal key point eGFR < 30 contraindicated（eGFR ≥ 45: Usual dose, eGFR 30–45: Do not start new; if already on, weigh risk/benefit and consider reducing (e.g. 500 mg qd), eGFR < 30: Contraindicated (lactic acidosis risk)）
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