🫘 Creatinine Clearance (Cockcroft-Gault)
UseRenal dose adjustment where labels reference creatinine clearance.
StrataMany drug labels still dose by estimated CrCl bands; choose actual, ideal or adjusted weight per the specific…
LimitsNot interchangeable with CKD-EPI eGFR for CKD staging. · Unstable creatinine, extremes of muscle mass and pregnancy reduce acc… · Confirm units (mg/dL vs µmol/L) before calculating.
SourceCockcroft DW, Gault MH. Nephron 1976
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Still referenced by many drug labels for dosing.
When to use
Renal dose adjustment where labels reference creatinine clearance.
How it works
CrCl = (140 − age) × weight × (0.85 if female) / (72 × SCr). SCr in mg/dL.
Key points
- Still referenced by many drug labels for dosing.
- Choose actual, ideal or adjusted weight per drug guidance.
- Not BSA-normalised — use CKD-EPI for CKD staging.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age | 60 years |
|---|---|
| Weight | 70 kg |
| Serum creatinine | 1.0 |
| Creatinine unit | mg/dL |
| Sex | Male |
→CrCl78mL/min
- Creatinine used：1 mg/dL
- Formula：(140−age)·weight·(0.85 if female) / (72·SCr)
- Note：Use actual body weight if not obese; consider ideal/adjusted weight in obesity.
| Age | 60 years |
|---|---|
| Weight | 70 kg |
| Serum creatinine | 80 |
| Creatinine unit | µmol/L |
| Sex | Female |
→CrCl73mL/min
- Creatinine used：80 µmol/L
- Formula：(140−age)·weight·(0.85 if female) / (72·SCr)
- Note：Use actual body weight if not obese; consider ideal/adjusted weight in obesity.
Verification & sources · governance
FAQ
Frequently asked questions
- Does Creatinine Clearance (Cockcroft-Gault) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Creatinine Clearance (Cockcroft-Gault) calculated in practice? Can you show a worked example?
- Inputs: Age 60 years, Weight 70 kg, Serum creatinine 1.0, Creatinine unit mg/dL, Sex Male → Result: CrCl 78 mL/min（Creatinine used: 1 mg/dL, Formula: (140−age)·weight·(0.85 if female) / (72·SCr), Note: Use actual body weight if not obese; consider ideal/adjusted weight in obesity.） Inputs: Age 60 years, Weight 70 kg, Serum creatinine 80, Creatinine unit µmol/L, Sex Female → Result: CrCl 73 mL/min（Creatinine used: 80 µmol/L, Formula: (140−age)·weight·(0.85 if female) / (72·SCr), Note: Use actual body weight if not obese; consider ideal/adjusted weight in obesity.）