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🫀 Liver Function Test Pattern Interpretation

UseClassify liver injury as hepatocellular, cholestatic or mixed to direct further testing.

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SourceAGA/ACG approach to abnormal liver chemistries (R factor)

Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders

This-shift next steps

After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.

Scene next step
📋labsOpen scene pack →
Related scores
Score + version; reference only — not a substitute for care · no HIS write

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Methodology · worked example, guidelines & full notes
Clinical takeaway

Albumin and INR reflect hepatic synthetic reserve.

When to use

Classify liver injury as hepatocellular, cholestatic or mixed to direct further testing.

How it works

R = (ALT/ULN) / (ALP/ULN): hepatocellular > 5, cholestatic < 2, mixed 2–5.

Key points

  • Albumin and INR reflect hepatic synthetic reserve.
  • Conjugated bilirubin > 20% of total suggests hepatobiliary disease.
  • Isolated ALP rise: check GGT to separate hepatic from bony source.
  • Isolated indirect bilirubin is usually Gilbert syndrome.

References

Worked calculation

The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.

ViewBilirubin

→PatternBilirubin

  • Indirect (unconjugated) ↑：Haemolysis, Gilbert, ineffective erythropoiesis
  • Direct (conjugated) ↑：Intra-/extrahepatic cholestasis, hepatocellular injury
  • Cue：Conjugated > 20% of total suggests hepatobiliary disease
ViewR-factor pattern

→PatternR-factor pattern

  • R factor：R = (ALT/ULN) / (ALP/ULN)
  • Hepatocellular：R > 5: viral/drug/alcohol/ischaemic/autoimmune/fatty liver
  • Cholestatic：R < 2: obstruction/PBC/PSC/drug/infiltration
Verification & sources · governance
FAQ

Frequently asked questions

What are the limits and cautions when using Liver Function Test Pattern Interpretation?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
Does Liver Function Test Pattern Interpretation upload patient data? Where is it calculated?
Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
How is Liver Function Test Pattern Interpretation calculated in practice? Can you show a worked example?
Inputs: View Bilirubin → Result: Pattern Bilirubin（Indirect (unconjugated) ↑: Haemolysis, Gilbert, ineffective erythropoiesis, Direct (conjugated) ↑: Intra-/extrahepatic cholestasis, hepatocellular injury, Cue: Conjugated > 20% of total suggests hepatobiliary disease） Inputs: View R-factor pattern → Result: Pattern R-factor pattern（R factor: R = (ALT/ULN) / (ALP/ULN), Hepatocellular: R > 5: viral/drug/alcohol/ischaemic/autoimmune/fatty liver, Cholestatic: R < 2: obstruction/PBC/PSC/drug/infiltration）
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