🫀 Maddrey Discriminant Function (Alcoholic Hepatitis)
UseDecide on corticosteroid therapy in alcoholic hepatitis.
StrataDF ≥32 defines severe alcoholic hepatitis historically considered for corticosteroids; reassess steroid respo…
LimitsPT/control lab methods vary — local assay calibration affects the DF. · Infection, GI bleed, and renal failure can contraindicate or delay st… · MELD and Lille often refine decisions beyond a single Maddrey thresho…
SourceMaddrey WC, et al. Gastroenterology 1978
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
DF ≥ 32 indicates severe disease with high short-term mortality.
When to use
Decide on corticosteroid therapy in alcoholic hepatitis.
How it works
DF = 4.6 × (patient PT − control PT) + total bilirubin (mg/dL). DF ≥ 32 = severe.
Key points
- DF ≥ 32 indicates severe disease with high short-term mortality.
- The classic threshold for considering corticosteroids.
- Reassess steroid response with the Lille score; MELD also used.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Patient prothrombin time | 20 s |
|---|---|
| Control PT | 12 s |
| Total bilirubin | 8 mg/dL |
→Maddrey DF44.8
- Interpretation：≥ 32: severe alcoholic hepatitis — consider corticosteroids (if no contraindication) and assess MELD/Lille.
- Formula：4.6 × (PT − control PT) + bilirubin (mg/dL)
Verification & sources · governance
FAQ
Frequently asked questions
- Does Maddrey Discriminant Function (Alcoholic Hepatitis) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Maddrey Discriminant Function (Alcoholic Hepatitis) calculated in practice? Can you show a worked example?
- Inputs: Patient prothrombin time 20 s, Control PT 12 s, Total bilirubin 8 mg/dL → Result: Maddrey DF 44.8（Interpretation: ≥ 32: severe alcoholic hepatitis — consider corticosteroids (if no contraindication) and assess MELD/Lille., Formula: 4.6 × (PT − control PT) + bilirubin (mg/dL)）