🧪 Anion Gap Calculator
UseEvaluate acid–base disorders; distinguish high- from normal-anion-gap acidosis.
SourceKraut JA, Madias NE. Clin J Am Soc Nephrol 2007. doi:10.2215/CJN.03020906
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
A high gap points to lactate, ketones, toxins or uraemia.
When to use
Evaluate acid–base disorders; distinguish high- from normal-anion-gap acidosis.
How it works
AG = Na − (Cl + HCO₃); reference ~8–12 mmol/L. Corrected AG = AG + 2.5 × (4 − albumin g/dL).
Key points
- A high gap points to lactate, ketones, toxins or uraemia.
- Low albumin lowers the measured gap — always correct it.
- Reference range is laboratory-dependent.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Sodium (Na⁺) | 140 mmol/L |
|---|---|
| Chloride (Cl⁻) | 104 mmol/L |
| Bicarbonate (HCO₃⁻) | 24 mmol/L |
| Albumin (optional) | 4.0 g/dL |
→Anion gap12.0mmol/L
- Formula：AG = Na − (Cl + HCO₃)
- Reference：8–12 mmol/L (lab-dependent)
- Albumin-corrected AG：12.0 mmol/L (+2.5 per 1 g/dL below 4)
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using Anion Gap Calculator?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does Anion Gap Calculator upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Anion Gap Calculator calculated in practice? Can you show a worked example?
- Inputs: Sodium (Na⁺) 140 mmol/L, Chloride (Cl⁻) 104 mmol/L, Bicarbonate (HCO₃⁻) 24 mmol/L, Albumin (optional) 4.0 g/dL → Result: Anion gap 12.0 mmol/L（Formula: AG = Na − (Cl + HCO₃), Reference: 8–12 mmol/L (lab-dependent), Albumin-corrected AG: 12.0 mmol/L (+2.5 per 1 g/dL below 4)）