🫀 CLIF-C ACLF Score
UseWhen to use: patients who already meet ACLF criteria on acute decompensation of cirrhosis.
StrataHigher scores track short-term mortality; serial values often outperform a single baseline.
LimitsWhen not to use: without ACLF diagnosis. · Pitfall: simplified circulation/respiration selects vs full CLIF tabl… · Not a listing score alone.
SourceCLIF-C ACLF (EF-CLIF / CANONIC)
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
OF + age + ln(WBC).
When to use
When to use: patients who already meet ACLF criteria on acute decompensation of cirrhosis.
How it works
CLIF-C ACLF = 10×(0.33×OF + 0.04×age + 0.63×ln(WBC) − 2).
Key points
- OF + age + ln(WBC).
- 0–100 scale.
- Next: transplant / goals of care.
References
- CLIF-C ACLF (EF-CLIF / CANONIC)
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Liver (bilirubin) | 6–<12 mg/dL (2) |
|---|---|
| Kidney (creatinine / RRT) | 2–<3.5 mg/dL (2) |
| Brain (HE West Haven) | Grade 1–2 (2) |
| Coagulation (INR) | INR 2–<2.5 (2) |
| Circulation | Use of vasoactives (2) |
| Respiration (P/F or S/F) | P/F 200–300 or S/F 214–357 (2) |
| Age | 55 years |
| WBC | 12 ×10⁹/L |
→CLIF-C ACLF57.3
- CLIF-C OF：12 (6–18)
- Age / WBC：55 y / 12.0 ×10⁹/L
- Cue：≈45–64 — intermediate risk band; serial reassessment useful
| Liver (bilirubin) | <6 mg/dL (1) |
|---|---|
| Kidney (creatinine / RRT) | <2 mg/dL (1) |
| Brain (HE West Haven) | Grade 0 (1) |
| Coagulation (INR) | INR <2 (1) |
| Circulation | MAP ≥70, no vasoactives (1) |
| Respiration (P/F or S/F) | P/F >300 or S/F >357 (1) |
| Age | 55 years |
| WBC | 12 ×10⁹/L |
→CLIF-C ACLF37.5
- CLIF-C OF：6 (6–18)
- Age / WBC：55 y / 12.0 ×10⁹/L
- Cue：<45 — lower short-term mortality band among ACLF (still sick)
Verification & sources · governance
FAQ
Frequently asked questions
- Does CLIF-C ACLF Score upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is CLIF-C ACLF Score calculated in practice? Can you show a worked example?
- Inputs: Liver (bilirubin) 6–<12 mg/dL (2), Kidney (creatinine / RRT) 2–<3.5 mg/dL (2), Brain (HE West Haven) Grade 1–2 (2), Coagulation (INR) INR 2–<2.5 (2), Circulation Use of vasoactives (2), Respiration (P/F or S/F) P/F 200–300 or S/F 214–357 (2), Age 55 years, WBC 12 ×10⁹/L → Result: CLIF-C ACLF 57.3（CLIF-C OF: 12 (6–18), Age / WBC: 55 y / 12.0 ×10⁹/L, Cue: ≈45–64 — intermediate risk band; serial reassessment useful） Inputs: Liver (bilirubin) <6 mg/dL (1), Kidney (creatinine / RRT) <2 mg/dL (1), Brain (HE West Haven) Grade 0 (1), Coagulation (INR) INR <2 (1), Circulation MAP ≥70, no vasoactives (1), Respiration (P/F or S/F) P/F >300 or S/F >357 (1), Age 55 years, WBC 12 ×10⁹/L → Result: CLIF-C ACLF 37.5（CLIF-C OF: 6 (6–18), Age / WBC: 55 y / 12.0 ×10⁹/L, Cue: <45 — lower short-term mortality band among ACLF (still sick)）