🧫 CISNE (Stable Febrile Neutropenia Risk)
UseSelect the six clinical features; the tool sums weighted points (0–8) and assigns low, intermediate, or high …
SourceCarmona-Bayonas A, et al. Prediction of serious complications in patients with seemingly stable feb…
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
CISNE applies only to patients who already appear stable, with no organ failure, shock, or severe infection (original synthesis · not guideline verbatim).
When to use
Select the six clinical features; the tool sums weighted points (0–8) and assigns low, intermediate, or high risk.
How it works
CISNE = 2×(ECOG ≥2) + 2×(stress hyperglycemia) + COPD + cardiovascular disease + mucositis ≥grade 2 + monocytes <200/μL. 0 low, 1–2 intermediate, ≥3 high.
Key points
- CISNE applies only to patients who already appear stable, with no organ failure, shock, or severe infection (original synthesis · not guideline verbatim).
- Serious complication rates in validation: 1.1% (low), 6.2% (intermediate), 36% (high).
- CISNE is more specific than MASCC in the emergency department, reducing misclassification of stable patients as low-risk.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| ECOG performance status ≥2 | Yes |
|---|---|
| Stress hyperglycemia | Yes |
| Chronic obstructive pulmonary disease | Yes |
| Chronic cardiovascular disease | Yes |
| Mucositis grade ≥2 (NCI) | Yes |
| Monocytes <200/μL | Yes |
→CISNE score8/8
- Risk group：High risk
- Serious complications (approx.)：≈36%
| ECOG performance status ≥2 | No |
|---|---|
| Stress hyperglycemia | No |
| Chronic obstructive pulmonary disease | No |
| Chronic cardiovascular disease | No |
| Mucositis grade ≥2 (NCI) | No |
| Monocytes <200/μL | No |
→CISNE score0/8
- Risk group：Low risk
- Serious complications (approx.)：≈1–2%
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using CISNE (Stable Febrile Neutropenia Risk)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does CISNE (Stable Febrile Neutropenia Risk) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is CISNE (Stable Febrile Neutropenia Risk) calculated in practice? Can you show a worked example?
- Inputs: ECOG performance status ≥2 Yes, Stress hyperglycemia Yes, Chronic obstructive pulmonary disease Yes, Chronic cardiovascular disease Yes, Mucositis grade ≥2 (NCI) Yes, Monocytes <200/μL Yes → Result: CISNE score 8 /8（Risk group: High risk, Serious complications (approx.): ≈36%） Inputs: ECOG performance status ≥2 No, Stress hyperglycemia No, Chronic obstructive pulmonary disease No, Chronic cardiovascular disease No, Mucositis grade ≥2 (NCI) No, Monocytes <200/μL No → Result: CISNE score 0 /8（Risk group: Low risk, Serious complications (approx.): ≈1–2%）