💊 CARG-TT Chemotherapy Toxicity (Older Adults)
UseWhen to use: adults ≥65 starting new cytotoxic chemotherapy.
StrataDerivation incidences ~30% / 52% / 83% for low / mid / high bands.
LimitsWhen not to use: non-cytotoxic targeted-only plans without adaptation. · Pitfall: CrCl formula mismatch. · Not a sole cancel-chemo order.
SourceCARG-TT (Hurria et al., JCO) chemotherapy toxicity in older adults
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Eleven items.
When to use
When to use: adults ≥65 starting new cytotoxic chemotherapy.
How it works
Weighted sum of 11 age/tumor/dose/lab/geriatric items (bands 0–5 / 6–9 / ≥10).
Key points
- Eleven items.
- Three bands.
- Next: geriatric assessment / dose support.
References
- CARG-TT (Hurria et al., JCO) chemotherapy toxicity in older adults
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age ≥72 years | No (0) |
|---|---|
| GI or GU cancer type | No / other (0) |
| Standard (full) chemotherapy dosing planned | Reduced dose (0) |
| Polychemotherapy (≥2 agents) | Monotherapy (0) |
| Anemia (Hb male <11 / female <10 g/dL) | No (0) |
| Creatinine clearance <34 mL/min | No (0) |
| Hearing fair or worse (with aid if used) | Good/excellent (0) |
| ≥1 fall in past 6 months | No (0) |
| Limited in walking one block | No (0) |
| Needs assistance taking medications | No (0) |
| Health limits social activity (some/most/all of time) | None/a little (0) |
→CARG-TT0points
- Risk band：Low (0–5) — derivation cohort ~30% grade 3–5 toxicity
| Age ≥72 years | Yes (+2) |
|---|---|
| GI or GU cancer type | Yes GI/GU (+2) |
| Standard (full) chemotherapy dosing planned | Standard dose (+2) |
| Polychemotherapy (≥2 agents) | Polychemotherapy (+2) |
| Anemia (Hb male <11 / female <10 g/dL) | Yes (+3) |
| Creatinine clearance <34 mL/min | Yes (+3) |
| Hearing fair or worse (with aid if used) | Fair or worse (+2) |
| ≥1 fall in past 6 months | Yes (+3) |
| Limited in walking one block | Yes (+2) |
| Needs assistance taking medications | Yes (+1) |
| Health limits social activity (some/most/all of time) | Some/most/all (+1) |
→CARG-TT23points
- Risk band：High (≥10) — ~83%
Verification & sources · governance
FAQ
Frequently asked questions
- Does CARG-TT Chemotherapy Toxicity (Older Adults) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is CARG-TT Chemotherapy Toxicity (Older Adults) calculated in practice? Can you show a worked example?
- Inputs: Age ≥72 years No (0), GI or GU cancer type No / other (0), Standard (full) chemotherapy dosing planned Reduced dose (0), Polychemotherapy (≥2 agents) Monotherapy (0), Anemia (Hb male <11 / female <10 g/dL) No (0), Creatinine clearance <34 mL/min No (0), Hearing fair or worse (with aid if used) Good/excellent (0), ≥1 fall in past 6 months No (0)… → Result: CARG-TT 0 points（Risk band: Low (0–5) — derivation cohort ~30% grade 3–5 toxicity） Inputs: Age ≥72 years Yes (+2), GI or GU cancer type Yes GI/GU (+2), Standard (full) chemotherapy dosing planned Standard dose (+2), Polychemotherapy (≥2 agents) Polychemotherapy (+2), Anemia (Hb male <11 / female <10 g/dL) Yes (+3), Creatinine clearance <34 mL/min Yes (+3), Hearing fair or worse (with aid if used) Fair or worse (+2), ≥1 fall in past 6 months Yes (+3)… → Result: CARG-TT 23 points（Risk band: High (≥10) — ~83%）