🧲 T2 / T2* Relaxometry & Iron Load (Liver LIC, Myocardial T2*)
UseIron-overload MRI in thalassemia and transfusion-dependent patients; quick checks of cartilage or myocardial …
SourceWood JC, et al. Blood 2005;106:1460-1465
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
R2* = 1000/T2*.
When to use
Iron-overload MRI in thalassemia and transfusion-dependent patients; quick checks of cartilage or myocardial T2 mapping.
How it works
T2 = (TE2 − TE1)/ln(S1/S2); R2* = 1000/T2*; LIC = 0.0254 × R2* + 0.202 (1.5 T, Wood 2005).
Key points
- R2* = 1000/T2*.
- LIC = 0.0254 × R2* + 0.202.
- Myocardial T2* <10 ms severe.
- 3 T values ≈ half of 1.5 T.
References
- Wood JC, et al. Blood 2005;106:1460-1465
- Anderson LJ, et al. Eur Heart J 2001;22:2171-2179
- Messroghli DR, et al. J Cardiovasc Magn Reson 2017;19:75
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| TE1 | 1.2 ms |
|---|---|
| Signal at TE1 | 900 |
| TE2 | 4.8 ms |
| Signal at TE2 | 420 |
| Tissue | Myocardium (T2*, iron) |
| Field strength | 1.5 T |
→T2 / T2*4.7ms
- T2 / T2*：4.72 ms ((TE2−TE1)/ln(S1/S2))
- R2 / R2*：211.7 s⁻¹
- Myocardial T2* (1.5 T equivalent)：4.7 ms — <10 ms: severe cardiac iron, high heart-failure risk
| TE1 | 1.2 ms |
|---|---|
| Signal at TE1 | 900 |
| TE2 | 4.8 ms |
| Signal at TE2 | 420 |
| Tissue | Liver (T2*, iron) |
| Field strength | 1.5 T |
→LIC5.6mg/g
- T2 / T2*：4.72 ms ((TE2−TE1)/ln(S1/S2))
- R2 / R2*：211.7 s⁻¹
- Liver iron concentration：5.6 mg Fe/g dry weight — Mild (1.8–7)
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using T2 / T2* Relaxometry & Iron Load (Liver LIC, Myocardial T2*)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does T2 / T2* Relaxometry & Iron Load (Liver LIC, Myocardial T2*) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is T2 / T2* Relaxometry & Iron Load (Liver LIC, Myocardial T2*) calculated in practice? Can you show a worked example?
- Inputs: TE1 1.2 ms, Signal at TE1 900, TE2 4.8 ms, Signal at TE2 420, Tissue Myocardium (T2*, iron), Field strength 1.5 T → Result: T2 / T2* 4.7 ms（T2 / T2*: 4.72 ms ((TE2−TE1)/ln(S1/S2)), R2 / R2*: 211.7 s⁻¹, Myocardial T2* (1.5 T equivalent): 4.7 ms — <10 ms: severe cardiac iron, high heart-failure risk） Inputs: TE1 1.2 ms, Signal at TE1 900, TE2 4.8 ms, Signal at TE2 420, Tissue Liver (T2*, iron), Field strength 1.5 T → Result: LIC 5.6 mg/g（T2 / T2*: 4.72 ms ((TE2−TE1)/ln(S1/S2)), R2 / R2*: 211.7 s⁻¹, Liver iron concentration: 5.6 mg Fe/g dry weight — Mild (1.8–7)）