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🧪 Sampson LDL-C Equation

UseWhen to use: lipid panels when Friedewald is unreliable (higher TG) and direct LDL unavailable.

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StrataCompare with non-HDL; prefer direct LDL if TG extreme or results discordant.

LimitsWhen not to use: chylomicronemia / TG extremely high. · Pitfall: mmol/L without conversion. · Martin–Hopkins is an alternative.

SourceSampson M et al. NIH LDL-C equation

Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders

This-shift next steps

After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.

Scene next step
📋ASCVD / China-PAROpen scene pack →
Related scores
Matching pathway
🧭htn_emergencyOpen pathway →
Score + version; reference only — not a substitute for care · no HIS write

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Methodology · worked example, guidelines & full notes
Clinical takeaway

Sampson–NIH.

When to use

When to use: lipid panels when Friedewald is unreliable (higher TG) and direct LDL unavailable.

How it works

LDL = TC/0.948 − HDL/0.971 − [TG/8.56 + (TG×nonHDL)/2140 − TG²/16100] − 9.44.

Key points

  • Sampson–NIH.
  • Wider TG than Friedewald.
  • Next: risk & therapy.

References

  • Sampson M et al. NIH LDL-C equation

Worked calculation

The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.

Total cholesterol200 mg/dL
HDL-C50 mg/dL
Triglycerides180 mg/dL

→Sampson LDL-C118.4mg/dL

  • non-HDL：150.0
  • Friedewald (ref)：114.0
  • TG note：TG <400 — compare with Friedewald/Martin–Hopkins as needed
Verification & sources · governance
FAQ

Frequently asked questions

Does Sampson LDL-C Equation upload patient data? Where is it calculated?
Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
How is Sampson LDL-C Equation calculated in practice? Can you show a worked example?
Inputs: Total cholesterol 200 mg/dL, HDL-C 50 mg/dL, Triglycerides 180 mg/dL → Result: Sampson LDL-C 118.4 mg/dL（non-HDL: 150.0, Friedewald (ref): 114.0, TG note: TG <400 — compare with Friedewald/Martin–Hopkins as needed）
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