💊 SAMe-TT₂R₂ Score (VKA TTR)
UseWhen to use: discussing VKA versus DOAC when TTR quality is uncertain.
StrataScores ≥2 associate with poorer TTR — consider DOAC or intensified INR monitoring if VKA used.
LimitsWhen not to use: replacing shared decision-making / local formulary. · Pitfall: ignoring bleeding risk scores. · Not a DOAC mandate.
SourceSAMe-TT₂R₂ (Apostolakis) published score
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
Paste the link in Slack, Teams, X, or LinkedIn — the preview image comes from this page’s Open Graph card.
Methodology · worked example, guidelines & full notes
Max 8; ≥2 poorer TTR cue.
When to use
When to use: discussing VKA versus DOAC when TTR quality is uncertain.
How it works
Female +1; age <60 +1; ≥2 comorbidities +1; interacting Rx +1; tobacco ≤2 y +2; non-white +2 (max 8).
Key points
- Max 8; ≥2 poorer TTR cue.
- AF VKA quality aid.
- Next: HAS-BLED / DOAC check.
References
- SAMe-TT₂R₂ (Apostolakis) published score
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Sex (female) | No (male) |
|---|---|
| Age < 60 years | No |
| Medical history ≥2 comorbidities | No |
| Interacting treatment (e.g. amiodarone) | No |
| Tobacco within 2 years | No |
| Non-white ethnicity | No |
→SAMe-TT₂R₂0/8
- Max：8
- Cue：0–1 — likelier acceptable TTR if VKA chosen (still individualize)
| Sex (female) | Yes (female) +1 |
|---|---|
| Age < 60 years | Yes +1 |
| Medical history ≥2 comorbidities | Yes +1 |
| Interacting treatment (e.g. amiodarone) | Yes +1 |
| Tobacco within 2 years | Yes +2 |
| Non-white ethnicity | Yes +2 |
→SAMe-TT₂R₂8/8
- Max：8
- Cue：≥2 — higher chance of suboptimal TTR on VKA; consider DOAC / closer INR monitoring
Verification & sources · governance
FAQ
Frequently asked questions
- Does SAMe-TT₂R₂ Score (VKA TTR) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is SAMe-TT₂R₂ Score (VKA TTR) calculated in practice? Can you show a worked example?
- Inputs: Sex (female) No (male), Age < 60 years No, Medical history ≥2 comorbidities No, Interacting treatment (e.g. amiodarone) No, Tobacco within 2 years No, Non-white ethnicity No → Result: SAMe-TT₂R₂ 0 /8（Max: 8, Cue: 0–1 — likelier acceptable TTR if VKA chosen (still individualize)） Inputs: Sex (female) Yes (female) +1, Age < 60 years Yes +1, Medical history ≥2 comorbidities Yes +1, Interacting treatment (e.g. amiodarone) Yes +1, Tobacco within 2 years Yes +2, Non-white ethnicity Yes +2 → Result: SAMe-TT₂R₂ 8 /8（Max: 8, Cue: ≥2 — higher chance of suboptimal TTR on VKA; consider DOAC / closer INR monitoring）